U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HNF4A-AS1 HNF4A antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 101927219, updated on 29-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
HNF4A-AS1provided by HGNC
Official Full Name
HNF4A antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:49505
See related
Ensembl:ENSG00000229005 AllianceGenome:HGNC:49505
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
uc002xlx
Expression
Biased expression in small intestine (RPKM 6.4), liver (RPKM 5.2) and 2 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HNF4A-AS1 in Genome Data Viewer
Location:
20q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44356744..44395706, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46091484..46130467, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42985384..43024346, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42938689-42939418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42939419-42940148 Neighboring gene fat storage inducing transmembrane protein 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42952746-42953298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42962599-42963110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42964365-42965354 Neighboring gene R3H domain containing like Neighboring gene R3HDML antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42981671-42982170 Neighboring gene hepatocyte nuclear factor 4 alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43017550-43018051 Neighboring gene microRNA 3646 Neighboring gene long intergenic non-protein coding RNA 1430

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells. Chen L, et al. Mol Pharmacol, 2020 Apr. PMID 32029527, Free PMC Article
  2. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Haberman Y, et al. Inflamm Bowel Dis, 2018 Jan 18. PMID 29361088, Free PMC Article
  3. Identification of expressed and conserved human noncoding RNAs. Nielsen MM, et al. RNA, 2014 Feb. PMID 24344320, Free PMC Article
  4. HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA. Jia W, et al. Int J Biol Sci, 2024. PMID 39430249, Free PMC Article
  5. HNF4A-AS1-encoded small peptide promotes self-renewal and aggressiveness of neuroblastoma stem cells via eEF1A1-repressed SMAD4 transactivation. Song H, et al. Oncogene, 2022 Apr. PMID 35318442

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA.
    Title: HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA.
  2. HNF4A-AS1-encoded small peptide promotes self-renewal and aggressiveness of neuroblastoma stem cells via eEF1A1-repressed SMAD4 transactivation.
    Title: HNF4A-AS1-encoded small peptide promotes self-renewal and aggressiveness of neuroblastoma stem cells via eEF1A1-repressed SMAD4 transactivation.
  3. Study identified two lncRNAs, HNF1A-AS1 and HNF4A-AS1, which were able to affect susceptibility of acetaminophen (APAP)-induced liver injury in HepaRG cells, possibly through regulating the expression of APAP-metabolizing cytochrome P450 enzymes. This discovery added new factors, lncRNAs, which can be used to predict cytochrome P450-mediated drug metabolism and drug-induced toxicity.
    Title: Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells.
  4. Co-expression and functional annotation enrichment analyses across several tissues and cell types showed that the upregulated LINC01272 is associated with a myeloid pro-inflammatory signature, whereas the downregulated HNF4A-AS1 exhibits association with an epithelial metabolic signature. The study identified significant correlations between LINC01272 and HNF4A-AS1 expression and more severe mucosal injury.
    Title: Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Homology

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_109949.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF143870
    Related
    ENST00000452481.1

  2. NR_172878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117382

  3. NR_172879.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117382
    Related
    ENST00000735375.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    44356744..44395706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    46091484..46130467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials