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Exoc8 exocyst complex component 8 [ Mus musculus (house mouse) ]

Gene ID: 102058, updated on 27-Nov-2024

Summary

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Official Symbol
Exoc8provided by MGI
Official Full Name
exocyst complex component 8provided by MGI
Primary source
MGI:MGI:2142527
See related
Ensembl:ENSMUSG00000074030 AllianceGenome:MGI:2142527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EXO84; SEC84; Exo84p
Summary
Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Predicted to be located in cell leading edge and late endosome. Predicted to be part of exocyst. Is expressed in several structures, including adrenal gland; genitourinary system; lung; nervous system; and pancreas. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Exoc8 in Genome Data Viewer
Location:
8 E2; 8 72.82 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125617038..125624444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124890299..124897705, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16163 Neighboring gene 40S small subunit processome assembly factor 1 Neighboring gene glyceronephosphate O-acyltransferase Neighboring gene SprT-like N-terminal domain Neighboring gene egl-9 family hypoxia-inducible factor 1 Neighboring gene predicted gene, 46060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking. Uhm M, et al. Sci Signal, 2017 Mar 21. PMID 28325821
  2. Arl13b and the exocyst interact synergistically in ciliogenesis. Seixas C, et al. Mol Biol Cell, 2016 Jan 15. PMID 26582389, Free PMC Article
  3. Exorcising the exocyst complex. Heider MR, et al. Traffic, 2012 Jul. PMID 22420621, Free PMC Article
  4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IEA
Inferred from Electronic Annotation
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst ISO
Inferred from Sequence Orthology
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 8
Names
exocyst complex 84 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198103.2 → NP_932771.1  exocyst complex component 8

    See identical proteins and their annotated locations for NP_932771.1

    Status: VALIDATED

    Source sequence(s)
    AC151736, AK054047, BC057052, BC094378
    Consensus CDS
    CCDS22777.1
    UniProtKB/Swiss-Prot
    Q6PGF7
    Related
    ENSMUSP00000095915.3, ENSMUST00000098312.4
    Conserved Domains (4) summary
    cd01226
    Location:167 → 279
    PH_RalBD_exo84; Exocyst complex 84-kDa subunit Ral-binding domain/Pleckstrin Homology (PH) domain
    pfam00169
    Location:174 → 273
    PH; PH domain
    pfam08700
    Location:13 → 97
    Vps51; Vps51/Vps67
    pfam16528
    Location:326 → 531
    Exo84_C; Exocyst component 84 C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125617038..125624444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGF7.1 GenPept UniProtKB/Swiss-Prot:Q6PGF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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