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Clk3 CDC-like kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 102414, updated on 27-Nov-2024

Summary

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Official Symbol
Clk3provided by MGI
Official Full Name
CDC-like kinase 3provided by MGI
Primary source
MGI:MGI:1098670
See related
Ensembl:ENSMUSG00000032316 AllianceGenome:MGI:1098670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Located in nucleus. Is expressed in several structures, including cerebral cortex; craniocervical region bone; ganglia; neural retina; and thyroid gland. Orthologous to human CLK3 (CDC like kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 73.1), liver E14.5 (RPKM 33.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Clk3 in Genome Data Viewer
Location:
9 B; 9 31.47 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57657904..57672397, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57750621..57766235, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Cyp1a2 5' enhancer Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene Cyp1a1 5' regulatory region Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 1 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene STARR-positive B cell enhancer ABC_E11409 Neighboring gene CapStarr-seq enhancers MGSCv37_chr9:57617333-57617516 and MGSCv37_chr9:57617555-57617846 Neighboring gene predicted gene, 32510 Neighboring gene AT-rich interaction domain 3B Neighboring gene STARR-seq mESC enhancer starr_24247 Neighboring gene STARR-positive B cell enhancer ABC_E2889 Neighboring gene STARR-positive B cell enhancer ABC_E6741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3. Xue M, et al. Cancer Med, 2023 Apr. PMID 36583532, Free PMC Article
  2. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. Ma X, et al. In Vitro Cell Dev Biol Anim, 2024 Apr. PMID 38438604
  3. Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Carrier A, et al. Immunogenetics, 1999 Dec. PMID 10630289
  4. Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Nayler O, et al. Biochem J, 1997 Sep 15. PMID 9307018, Free PMC Article
  5. Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Zhou J, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Dec. PMID 29055695

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
    Title: CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
  2. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
    Title: MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36552, MGC103028

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein kinase CLK3
Names
cdc2/CDC28-like protein kinase 3
NP_001397105.1
NP_001397106.1
NP_001397107.1
NP_001397108.1
NP_001397109.1
NP_001397110.1
NP_001397111.1
NP_031739.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410176.1 → NP_001397105.1  dual specificity protein kinase CLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122515
    UniProtKB/Swiss-Prot
    O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
    UniProtKB/TrEMBL
    A0A8Z1S2G3

  2. NM_001410177.1 → NP_001397106.1  dual specificity protein kinase CLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122515
    UniProtKB/Swiss-Prot
    O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
    UniProtKB/TrEMBL
    A0A8Z1S2G3

  3. NM_001410178.1 → NP_001397107.1  dual specificity protein kinase CLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122515
    UniProtKB/Swiss-Prot
    O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
    UniProtKB/TrEMBL
    A0A8Z1S2G3

  4. NM_001410179.1 → NP_001397108.1  dual specificity protein kinase CLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122515
    UniProtKB/Swiss-Prot
    O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
    UniProtKB/TrEMBL
    A0A8Z1S2G3

  5. NM_001410180.1 → NP_001397109.1  dual specificity protein kinase CLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122515
    UniProtKB/Swiss-Prot
    O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
    UniProtKB/TrEMBL
    A0A8Z1S2G3

  6. NM_001410181.1 → NP_001397110.1  dual specificity protein kinase CLK3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122515

  7. NM_001410182.1 → NP_001397111.1  dual specificity protein kinase CLK3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122515

  8. NM_007713.5 → NP_031739.4  dual specificity protein kinase CLK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122515
    Consensus CDS
    CCDS23232.1
    UniProtKB/Swiss-Prot
    O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
    UniProtKB/TrEMBL
    A0A1L1SST3, A0A8Z1S2G3
    Related
    ENSMUSP00000067341.8, ENSMUST00000065330.8
    Conserved Domains (1) summary
    cd14214
    Location:142 → 472
    PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57657904..57672397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35492.3 GenPept UniProtKB/Swiss-Prot:O35492

Gene LinkOut

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