Percc1 proline and glutamate rich with coiled coil 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Percc1provided by MGI
Official Full Name: proline and glutamate rich with coiled coil 1provided by MGI
Primary source: MGI:MGI:5621540
See related: Ensembl:ENSMUSG00000114245 AllianceGenome:MGI:5621540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm38655
Summary: Involved in digestive tract morphogenesis and enteroendocrine cell differentiation. Is expressed in duodenum; pancreas; and stomach. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PERCC1 (proline and glutamate rich with coiled coil 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in lung adult (RPKM 2.3), stomach adult (RPKM 1.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25390128..25399792, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25171154..25180818, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Percc1-knockout mice displayed phenotypes similar to those observed upon intestine-critical region (ICR) deletion in mice and patients, whereas an ICR-driven Percc1 transgene was sufficient to rescue the phenotypes found in mice that lacked the ICR; noncoding deletions identify a gene (Percc1) that is critical for intestinal function
Title: Noncoding deletions reveal a gene that is critical for intestinal function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteroendocrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein PERCC1

Names: proline and glutamage-rich protein with a coiled coil domain; protein LOC105371045 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.