U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tcta T cell leukemia translocation altered gene [ Mus musculus (house mouse) ]

Gene ID: 102791, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Tctaprovided by MGI
Official Full Name
T cell leukemia translocation altered geneprovided by MGI
Primary source
MGI:MGI:1918829
See related
Ensembl:ENSMUSG00000039461 AllianceGenome:MGI:1918829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tctal; 9130410M22Rik
Summary
Predicted to be involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and trigeminal nerve. Orthologous to human TCTA (T cell leukemia translocation altered). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 28.4), genital fat pad adult (RPKM 27.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tcta in Genome Data Viewer
Location:
9 F2; 9 59.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108180157..108183174, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108302955..108306159, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2915 Neighboring gene nicolin 1 Neighboring gene aminomethyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E6805 Neighboring gene ras homolog family member A Neighboring gene STARR-seq mESC enhancer starr_25204 Neighboring gene STARR-seq mESC enhancer starr_25205 Neighboring gene glutathione peroxidase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Aplan PD, et al. Cancer Res, 1995 May 1. PMID 7728759
  2. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Persons DA, et al. Nat Genet, 1999 Oct. PMID 10508511
  3. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osteoclast fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
T-cell leukemia translocation-altered gene protein homolog
Names
T-cell leukemia translocation altered

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311156.2 → NP_001298085.1  T-cell leukemia translocation-altered gene protein homolog isoform 2

    See identical proteins and their annotated locations for NP_001298085.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC161260
    Consensus CDS
    CCDS81073.1
    UniProtKB/TrEMBL
    A0A0A6YXI4
    Related
    ENSMUSP00000142002.2, ENSMUST00000192886.6
    Conserved Domains (1) summary
    pfam15128
    Location:15 → 106
    T_cell_tran_alt; T-cell leukemia translocation-altered

  2. NM_133986.3 → NP_598747.1  T-cell leukemia translocation-altered gene protein homolog isoform 1

    See identical proteins and their annotated locations for NP_598747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161260
    Consensus CDS
    CCDS23520.1
    UniProtKB/Swiss-Prot
    Q8VEA7
    Related
    ENSMUSP00000045063.8, ENSMUST00000044725.9
    Conserved Domains (1) summary
    pfam15128
    Location:15 → 122
    T_cell_tran_alt; T-cell leukemia translocation-altered

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108180157..108183174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEA7.1 GenPept UniProtKB/Swiss-Prot:Q8VEA7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools