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Zfp420 zinc finger protein 420 [ Rattus norvegicus (Norway rat) ]

Gene ID: 103690163, updated on 27-Nov-2024

Summary

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Symbol
Zfp420provided by RGD
Full Name
zinc finger protein 420provided by RGD
Primary source
RGD:2323829
See related
EnsemblRapid:ENSRNOG00000020774 AllianceGenome:RGD:2323829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst hatching. Predicted to be active in nucleus. Orthologous to several human genes including ZNF420 (zinc finger protein 420). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 47.7), Brain (RPKM 46.9) and 9 other tissues See more
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Genomic context

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See Zfp420 in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94259715..94271102)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85092810..85143682)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88204836..88216548)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 420 Neighboring gene zinc finger protein 27 Neighboring gene zinc finger protein 74 Neighboring gene uncharacterized LOC103691076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation by p53. Beckerman R, et al. Cold Spring Harb Perspect Biol, 2010 Aug. PMID 20679336, Free PMC Article
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 383; zinc finger protein 420
Names
Zinc finger protein 420-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432916.1 → NP_001419845.1  zinc finger protein 420 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  2. NM_001432917.1 → NP_001419846.1  zinc finger protein 420 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    M0R494

  3. NM_001432918.1 → NP_001419847.1  zinc finger protein 420 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001432919.1 → NP_001419848.1  zinc finger protein 420 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  5. NM_001432920.1 → NP_001419849.1  zinc finger protein 420 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    94259715..94271102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093741.2 → XP_038949669.1  zinc finger protein 383 isoform X1

    UniProtKB/TrEMBL
    M0R5R2
    Related
    ENSRNOP00000064174.4, ENSRNOT00000072556.4
    Conserved Domains (5) summary
    smart00349
    Location:66 → 127
    KRAB; krueppel associated box
    COG5048
    Location:285 → 529
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224 → 246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:266 → 291
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006228747.5 → XP_006228809.1  zinc finger protein 383 isoform X2

    See identical proteins and their annotated locations for XP_006228809.1

    UniProtKB/TrEMBL
    M0R5R2
    Related
    ENSRNOP00000064739.4, ENSRNOT00000074580.4
    Conserved Domains (6) summary
    smart00349
    Location:66 → 126
    KRAB; krueppel associated box
    COG5048
    Location:284 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:475 → 497
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:66 → 105
    KRAB; KRAB box
    pfam13465
    Location:378 → 402
    zf-H2C2_2; Zinc-finger double domain

  3. XM_039093752.2 → XP_038949680.1  zinc finger protein 383 isoform X7

    Conserved Domains (4) summary
    smart00349
    Location:12 → 73
    KRAB; krueppel associated box
    COG5048
    Location:231 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312 → 332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212 → 237
    zf-H2C2_2; Zinc-finger double domain

  4. XM_039093746.2 → XP_038949674.1  zinc finger protein 383 isoform X5

    Conserved Domains (4) summary
    smart00349
    Location:27 → 88
    KRAB; krueppel associated box
    COG5048
    Location:246 → 490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:227 → 252
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006228749.5 → XP_006228811.1  zinc finger protein 383 isoform X6

    Conserved Domains (6) summary
    smart00349
    Location:27 → 87
    KRAB; krueppel associated box
    COG5048
    Location:245 → 489
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:436 → 458
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:339 → 363
    zf-H2C2_2; Zinc-finger double domain

  6. XM_039093743.2 → XP_038949671.1  zinc finger protein 383 isoform X3

    Conserved Domains (4) summary
    smart00349
    Location:35 → 96
    KRAB; krueppel associated box
    COG5048
    Location:254 → 498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335 → 355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:235 → 260
    zf-H2C2_2; Zinc-finger double domain

  7. XM_039093751.2 → XP_038949679.1  zinc finger protein 383 isoform X7

    Conserved Domains (4) summary
    smart00349
    Location:12 → 73
    KRAB; krueppel associated box
    COG5048
    Location:231 → 475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312 → 332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212 → 237
    zf-H2C2_2; Zinc-finger double domain

  8. XM_063277766.1 → XP_063133836.1  zinc finger protein 383 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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