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Ctsq cathepsin Q [ Mus musculus (house mouse) ]

Gene ID: 104002, updated on 4-Jan-2025

Summary

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Official Symbol
Ctsqprovided by MGI
Official Full Name
cathepsin Qprovided by MGI
Primary source
MGI:MGI:2137385
See related
Ensembl:ENSMUSG00000021439 AllianceGenome:MGI:2137385
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1600010J02Rik
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in extraembryonic component; head; pituitary gland; placenta; and trophoblast giant cell. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward placenta adult (RPKM 51.4) See more
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Genomic context

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See Ctsq in Genome Data Viewer
Location:
13 B2; 13 32.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61182852..61188411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61035038..61040597, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40976 Neighboring gene predicted gene, 40975 Neighboring gene cathepsin J Neighboring gene STARR-seq mESC enhancer starr_34744 Neighboring gene STARR-seq mESC enhancer starr_34745 Neighboring gene zinc finger protein 930 pseudogene Neighboring gene cathepsin R

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Tu HC, et al. Proc Natl Acad Sci U S A, 2009 Jan 27. PMID 19144918, Free PMC Article
  2. Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta. Sol-Church K, et al. Biochem Biophys Res Commun, 2000 Jan 27. PMID 10673370
  3. Cathepsin gene expression in mouse placenta during the latter half of pregnancy. Ishida M, et al. J Reprod Dev, 2004 Oct. PMID 15514457
  4. PTHrP is essential for normal morphogenetic and functional development of the murine placenta. Duval C, et al. Dev Biol, 2017 Oct 15. PMID 28864069
  5. Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Simmons DG, et al. Dev Biol, 2007 Apr 15. PMID 17289015

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The p53-cathepsin axis is the quintessential framework underlying necrotic cell death.
    Title: The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage.
  2. Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice.
    Title: Cathepsin gene expression in mouse placenta during the latter half of pregnancy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cathepsin Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029636.3 → NP_083912.2  cathepsin Q precursor

    See identical proteins and their annotated locations for NP_083912.2

    Status: PROVISIONAL

    Source sequence(s)
    AC160115
    Consensus CDS
    CCDS26584.1
    UniProtKB/TrEMBL
    Q91ZF4
    Related
    ENSMUSP00000021888.8, ENSMUST00000021888.9
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:125 → 342
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61182852..61188411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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