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Meig1 meiosis expressed gene 1 [ Mus musculus (house mouse) ]

Gene ID: 104362, updated on 27-Nov-2024

Summary

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Official Symbol
Meig1provided by MGI
Official Full Name
meiosis expressed gene 1provided by MGI
Primary source
MGI:MGI:1202878
See related
Ensembl:ENSMUSG00000026650 AllianceGenome:MGI:1202878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meg1; MLZ-278
Summary
Acts upstream of or within manchette assembly and protein localization. Located in cytosol; manchette; and nucleus. Is expressed in ovary; retina; and testis. Orthologous to human MEIG1 (meiosis/spermiogenesis associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 245.0) See more
Orthologs
human all
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Genomic context

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See Meig1 in Genome Data Viewer
Location:
2 A1; 2 1.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3410080..3423685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3409043..3422648, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oleoyl-ACP hydrolase Neighboring gene STARR-seq mESC enhancer starr_03512 Neighboring gene predicted gene, 39750 Neighboring gene STARR-positive B cell enhancer ABC_E5880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:3341062-3341360 Neighboring gene DNA cross-link repair 1C Neighboring gene STARR-seq mESC enhancer starr_03514 Neighboring gene suppressor of variegation 3-9 2 Neighboring gene STARR-seq mESC enhancer starr_03515 Neighboring gene predicted gene, 54099 Neighboring gene heat shock protein 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation. Li W, et al. J Biol Chem, 2021 Nov. PMID 34673028, Free PMC Article
  2. Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Don J, et al. Cell Growth Differ, 1992 Aug. PMID 1390336
  3. Characterization of male meiotic germ cell-specific antigen (Meg 1) by monoclonal antibody TRA 369 in mice. Watanabe D, et al. Mol Reprod Dev, 1992 Nov. PMID 1449797
  4. Developmentally regulated expression during gametogenesis of the murine gene meg1 suggests a role in meiosis. Don J, et al. Mol Reprod Dev, 1994 May. PMID 8049060
  5. Two alternatively spliced Meig1 messenger RNA species are differentially expressed in the somatic and in the germ-cell compartments of the testis. Ever L, et al. Cell Growth Differ, 1999 Jan. PMID 9950214

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.
    Title: MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.
  2. A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation.
    Title: A single amino acid mutation in the mouse MEIG1 protein disrupts a cargo transport system necessary for sperm formation.
  3. Mouse meiosis expressed gene 1 is not phosphorylated in vivo.
    Title: Mouse meiosis expressed gene 1 is not phosphorylated in vivo.
  4. MORN3 is another regulator for spermatogenesis, probably together with MEIG1.
    Title: Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells.
  5. Studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella.
    Title: A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.
  6. Suggests that MEIG1 regulates spermiogenesis through effects in germ cells alone, and that the Meig1 gene must be active during a discrete period in spermatogenesis after which it is dispensable.
    Title: Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice.
  7. late spermiogenesis is the differentiative stage at which MEIG1's function is crucial
    Title: Meig1 deficiency causes a severe defect in mouse spermatogenesis.
  8. Findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis.
    Title: MEIG1 is essential for spermiogenesis in mice.
  9. Meig1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within manchette assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
meiosis-expressed gene 1 protein
Names
protein expressed in male leptotene and zygotene spermatocytes 278

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355205.1 → NP_001342134.1  meiosis-expressed gene 1 protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six transcripts encode the same protein.
    Source sequence(s)
    AL732620
    Consensus CDS
    CCDS38038.1
    UniProtKB/Swiss-Prot
    Q61845
    UniProtKB/TrEMBL
    Q8CF17
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

  2. NM_001355207.1 → NP_001342136.1  meiosis-expressed gene 1 protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
    Source sequence(s)
    AL732620
    Consensus CDS
    CCDS38038.1
    UniProtKB/Swiss-Prot
    Q61845
    UniProtKB/TrEMBL
    Q8CF17
    Related
    ENSMUSP00000110734.4, ENSMUST00000115082.10
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

  3. NM_001355208.1 → NP_001342137.1  meiosis-expressed gene 1 protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
    Source sequence(s)
    AL732620
    Consensus CDS
    CCDS38038.1
    UniProtKB/Swiss-Prot
    Q61845
    UniProtKB/TrEMBL
    Q8CF17
    Related
    ENSMUSP00000110736.2, ENSMUST00000115084.8
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

  4. NM_001355209.1 → NP_001342138.1  meiosis-expressed gene 1 protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
    Source sequence(s)
    AL732620
    Consensus CDS
    CCDS38038.1
    UniProtKB/Swiss-Prot
    Q61845
    UniProtKB/TrEMBL
    Q8CF17
    Related
    ENSMUSP00000110735.2, ENSMUST00000115083.8
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

  5. NM_001355210.1 → NP_001342139.1  meiosis-expressed gene 1 protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
    Source sequence(s)
    AL732620
    Consensus CDS
    CCDS38038.1
    UniProtKB/Swiss-Prot
    Q61845
    UniProtKB/TrEMBL
    Q8CF17
    Related
    ENSMUSP00000110733.2, ENSMUST00000115081.8
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

  6. NM_008579.4 → NP_032605.1  meiosis-expressed gene 1 protein

    See identical proteins and their annotated locations for NP_032605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six transcripts encode the same protein.
    Source sequence(s)
    BC049538
    Consensus CDS
    CCDS38038.1
    UniProtKB/Swiss-Prot
    Q61845
    UniProtKB/TrEMBL
    Q8CF17
    Related
    ENSMUSP00000070310.8, ENSMUST00000064685.14
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3410080..3423685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61845.1 GenPept UniProtKB/Swiss-Prot:Q61845

Gene LinkOut

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