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Slc25a47 solute carrier family 25, member 47 [ Mus musculus (house mouse) ]

Gene ID: 104910, updated on 27-Nov-2024

Summary

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Official Symbol
Slc25a47provided by MGI
Official Full Name
solute carrier family 25, member 47provided by MGI
Primary source
MGI:MGI:2144766
See related
Ensembl:ENSMUSG00000048856 AllianceGenome:MGI:2144766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HDMCP
Summary
Enables NAD transmembrane transporter activity and acetyl-CoA transmembrane transporter activity. Predicted to be involved in NAD transmembrane transport and acetyl-CoA transport. Located in mitochondrial inner membrane and mitochondrial outer membrane. Is expressed in liver and metanephros. Orthologous to human SLC25A47 (solute carrier family 25 member 47). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 215.8), liver E18 (RPKM 48.5) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Slc25a47 in Genome Data Viewer
Location:
12 F1; 12 59.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108815740..108822741)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108849833..108856815)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7179 Neighboring gene solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29 Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345 Neighboring gene predicted gene, 22079 Neighboring gene tryptophanyl-tRNA synthetase1 Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene WD repeat domain 25 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene peptidyl prolyl isomerase H pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis. Cheng L, et al. Hepatology, 2023 Dec 1. PMID 36804859, Free PMC Article
  2. Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis. Jin X, et al. PLoS One, 2017. PMID 28346483, Free PMC Article
  3. The SLC25A47 locus controls gluconeogenesis and energy expenditure. Yook JS, et al. Proc Natl Acad Sci U S A, 2023 Feb 28. PMID 36812201, Free PMC Article
  4. Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein. Tan MG, et al. J Biol Chem, 2004 Oct 22. PMID 15322095
  5. The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. Bresciani N, et al. J Hepatol, 2022 Oct. PMID 35714811

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis.
    Title: Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
  2. The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis.
    Title: The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis.
  3. Increased HDMCP expression was identified in nonalcoholic steatohepatitis animal model and HFFA-72h cultured L02 cell. Moreover, under regulation of miR-146, nonalcoholic steatohepatitis alleviation was achieved after HDMCP downregulation in both in vivo and in vitro, according to the declination of steatosis and inflammation related markers.
    Title: Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis.
  4. hepatocellular carcinoma down-regulated mitochondrial carrier protein is a novel liver-specific uncoupling protein
    Title: Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC107675

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetyl-CoA transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NAD transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in acetyl-CoA transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 47
Names
hepatocellular carcinoma down-regulated mitochondrial carrier homolog
mitochondrial NAD(+) transporter SLC25A47
mitochondrial hepatocellular carcinoma-downregulated carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012310.2 → NP_001012310.2  solute carrier family 25 member 47

    See identical proteins and their annotated locations for NP_001012310.2

    Status: VALIDATED

    Source sequence(s)
    AI173533, AK149369
    Consensus CDS
    CCDS26165.1
    UniProtKB/Swiss-Prot
    Q3UES2, Q5FW58, Q6IS41, Q7TPP3
    Related
    ENSMUSP00000050329.9, ENSMUST00000057026.10
    Conserved Domains (1) summary
    pfam00153
    Location:215 → 304
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108815740..108822741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243981.4 → XP_011242283.1  solute carrier family 25 member 47 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:226 → 307
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IS41.2 GenPept UniProtKB/Swiss-Prot:Q6IS41

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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