Iars1 isoleucyl-tRNA synthetase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iars1provided by MGI
Official Full Name: isoleucyl-tRNA synthetase 1provided by MGI
Primary source: MGI:MGI:2145219
See related: Ensembl:ENSMUSG00000037851 AllianceGenome:MGI:2145219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ILRS; Iars; 2510016L12Rik; E430001P04Rik
Summary: Enables isoleucine-tRNA ligase activity. Involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 23.5), CNS E11.5 (RPKM 22.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.38 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49835606..49887743)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49682130..49734267)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI327140 (e-PCR)
- UniSTS:180529

NoName (e-PCR)
- UniSTS:234076

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables isoleucine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isoleucine-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables isoleucine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables isoleucine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity	IEA Inferred from Electronic Annotation more info
involved_in isoleucyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoleucyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within isoleucyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in isoleucyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isoleucine--tRNA ligase, cytoplasmic

Names: IRS; ileRS; isoleucine-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic

NP_742012.2

EC 6.1.1.5

XP_006516889.1

EC 6.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.