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LUADT1 lung adenocarcinoma associated transcript 1 [ Homo sapiens (human) ]

Gene ID: 106182249, updated on 10-Dec-2024

Summary

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Official Symbol
LUADT1provided by HGNC
Official Full Name
lung adenocarcinoma associated transcript 1provided by HGNC
Primary source
HGNC:HGNC:51845
See related
Ensembl:ENSG00000196634 AllianceGenome:HGNC:51845
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

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See LUADT1 in Genome Data Viewer
Location:
6q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (147158925..147180992)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (148352193..148374261)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (147480061..147502128)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene androglobin Neighboring gene uncharacterized LOC105378040 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:147150949-147151716 Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25232 Neighboring gene STXBP5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17645 Neighboring gene Sharpr-MPRA regulatory region 4352 Neighboring gene Sharpr-MPRA regulatory region 12413 Neighboring gene Sharpr-MPRA regulatory region 4624 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:147365163-147366362 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:147374300-147374964 Neighboring gene uncharacterized LOC124901422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17649 Neighboring gene syntaxin binding protein 5 Neighboring gene MPRA-validated peak6197 silencer Neighboring gene MPRA-validated peak6199 silencer Neighboring gene MPRA-validated peak6200 silencer Neighboring gene uncharacterized LOC124901421

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA LUADT1 is Upregulated in Mantle Cell Lymphoma and Modulates TRIM11 by Sponging miR-24-3p to Inhibit Cell Apoptosis. Dong L, et al. Crit Rev Eukaryot Gene Expr, 2021. PMID 34591388
  2. LncRNALUADT1 is overexpressed in colorectal cancer and its expression level is related to clinicopathology. Zhang XF, et al. Eur Rev Med Pharmacol Sci, 2018 Apr. PMID 29762830
  3. LncRNA LUADT1 sponges miR-195 to prevent cardiac endothelial cell apoptosis in sepsis. Zhang Z, et al. Mol Med, 2020 Nov 23. PMID 33225891, Free PMC Article
  4. LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis. Dai R, et al. Arch Physiol Biochem, 2022 Jun. PMID 32125187
  5. LncRNA LUADT1 sponges miR-15a-3p to upregulate Twist1 in small cell lung cancer. Wang D, et al. BMC Pulm Med, 2019 Dec 16. PMID 31842825, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis.
    Title: LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis.
  2. LncRNA LUADT1 is Upregulated in Mantle Cell Lymphoma and Modulates TRIM11 by Sponging miR-24-3p to Inhibit Cell Apoptosis.
    Title: LncRNA LUADT1 is Upregulated in Mantle Cell Lymphoma and Modulates TRIM11 by Sponging miR-24-3p to Inhibit Cell Apoptosis.
  3. LncRNA LUADT1 sponges miR-195 to prevent cardiac endothelial cell apoptosis in sepsis.
    Title: LncRNA LUADT1 sponges miR-195 to prevent cardiac endothelial cell apoptosis in sepsis.
  4. The study found that LUADT1 and Twist1 were upregulated in small cell lung cancer (SCLC), while miR-15a-3p was downregulated in SCLC.
    Title: LncRNA LUADT1 sponges miR-15a-3p to upregulate Twist1 in small cell lung cancer.
  5. LncRNA LUADT1 might contribute to the development of colorectal cancer.
    Title: LncRNALUADT1 is overexpressed in colorectal cancer and its expression level is related to clinicopathology.
  6. A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27.
    Title: A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_132442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL356415, N24013, N35358
    Related
    ENST00000359838.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    147158925..147180992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    148352193..148374261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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