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Gramd2b GRAM domain containing 2B [ Mus musculus (house mouse) ]

Gene ID: 107022, updated on 27-Nov-2024

Summary

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Official Symbol
Gramd2bprovided by MGI
Official Full Name
GRAM domain containing 2Bprovided by MGI
Primary source
MGI:MGI:1914815
See related
Ensembl:ENSMUSG00000001700 AllianceGenome:MGI:1914815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gramd3; NS3TP2; 9030613F08Rik; 9130427A09Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be active in cytoplasmic microtubule. Orthologous to human GRAMD2B (GRAM domain containing 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E18 (RPKM 10.1), large intestine adult (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gramd2b in Genome Data Viewer
Location:
18 D3; 18 30.43 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56533412..56636864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56387485..56503792)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene RIKEN cDNA 4930511P09 gene Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11659 Neighboring gene STARR-positive B cell enhancer ABC_E8927 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:56615334-56615595 Neighboring gene STARR-seq mESC enhancer starr_44663 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene aldehyde dehydrogenase family 7, member A1 Neighboring gene microRNA 1258

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
GRAM domain-containing protein 2B
Names
GRAM domain containing 3
GRAM domain-containing protein 3
HCV NS3-transactivated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360917.1 → NP_001347846.1  GRAM domain-containing protein 2B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC120797, AC162035
    Consensus CDS
    CCDS89243.1
    UniProtKB/Swiss-Prot
    E9Q8C6, Q6PEM6
    Related
    ENSMUSP00000157609.2, ENSMUST00000237422.2
    Conserved Domains (1) summary
    cd13220
    Location:135 → 227
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  2. NM_026240.2 → NP_080516.2  GRAM domain-containing protein 2B isoform 2

    See identical proteins and their annotated locations for NP_080516.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK164050, BE198493, BY112662
    Consensus CDS
    CCDS50290.1
    UniProtKB/TrEMBL
    Q9D2W5, Q9D318
    Related
    ENSMUSP00000068453.6, ENSMUST00000070166.6
    Conserved Domains (1) summary
    cd13220
    Location:122 → 214
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56533412..56636864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEM6.2 GenPept UniProtKB/Swiss-Prot:Q6PEM6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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