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Prl2c5 prolactin family 2, subfamily c, member 5 [ Mus musculus (house mouse) ]

Gene ID: 107849, updated on 27-Nov-2024

Summary

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Official Symbol
Prl2c5provided by MGI
Official Full Name
prolactin family 2, subfamily c, member 5provided by MGI
Primary source
MGI:MGI:1858413
See related
Ensembl:ENSMUSG00000055360 AllianceGenome:MGI:1858413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghd3; MRP-4; PLF-4; Mrpplf4
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 899.8) See more
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Genomic context

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See Prl2c5 in Genome Data Viewer
Location:
13 A1; 13 5.21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (13357288..13366515)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13182703..13191930)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9628 Neighboring gene R3H domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33675 Neighboring gene lysophosphatidylcholine acyltransferase 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33676 Neighboring gene predicted gene 2423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mrp4, a new mitogen-regulated protein/proliferin gene; unique in this gene family for its expression in the adult mouse tail and ear. Fassett JT, et al. Endocrinology, 2000 May. PMID 10803597
  2. Proliferin enhances microvilli formation and cell growth of neuroblastoma cells. Wang JW, et al. Neurosci Res, 2006 Sep. PMID 16876275
  3. HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2. Sallais J, et al. JCI Insight, 2022 Dec 8. PMID 36227697, Free PMC Article
  4. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360
  5. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prolactin-2C5
Names
growth hormone d3
mitogen regulated protein, proliferin 4
mitogen-regulated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311129.1 → NP_001298058.1  prolactin-2C5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001298058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145824, CT030187
    Consensus CDS
    CCDS79164.1
    UniProtKB/TrEMBL
    Q6P215, Q7TND2
    Related
    ENSMUSP00000115024.2, ENSMUST00000126540.8
    Conserved Domains (1) summary
    pfam00103
    Location:36 → 225
    Hormone_1; Somatotropin hormone family

  2. NM_181852.2 → NP_862900.1  prolactin-2C5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_862900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an upstream start codon compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CT030187
    Consensus CDS
    CCDS26242.1
    UniProtKB/Swiss-Prot
    Q3UKX5, Q9JLV9
    UniProtKB/TrEMBL
    Q6P215, Q7TND2
    Related
    ENSMUSP00000021778.8, ENSMUST00000021778.14
    Conserved Domains (1) summary
    pfam00103
    Location:24 → 222
    Hormone_1; Somatotropin hormone family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    13357288..13366515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244261.1 → XP_011242563.1  prolactin-2C5 isoform X2

    UniProtKB/TrEMBL
    Q6P215, Q7TND2
    Conserved Domains (1) summary
    pfam00103
    Location:24 → 224
    Hormone_1; Somatotropin hormone family

  2. XM_011244260.3 → XP_011242562.1  prolactin-2C5 isoform X1

    UniProtKB/TrEMBL
    Q6P215, Q7TND2
    Conserved Domains (1) summary
    pfam00103
    Location:27 → 227
    Hormone_1; Somatotropin hormone family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLV9.1 GenPept UniProtKB/Swiss-Prot:Q9JLV9

Gene LinkOut

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