Srsf9 serine and arginine-rich splicing factor 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srsf9provided by MGI
Official Full Name: serine and arginine-rich splicing factor 9provided by MGI
Primary source: MGI:MGI:104896
See related: Ensembl:ENSMUSG00000029538 AllianceGenome:MGI:104896
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 25kDa; Sfrs9; SRp30c; 2610029M16Rik
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 57.7), ovary adult (RPKM 45.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.05 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115465236..115471139)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115327163..115333843)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
Title: The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
Data show that editing of Cav1.3 calcium channel (CaV1.3) was potently inhibited by serine/arginine-rich splicing factor 9 (SRSF9).
Title: Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9.
cooperative action of multiple SR proteins in the regulation of GnRH pre-mRNA splicing; SRp30c specifically binds to both ESE3 and ESE4
Title: Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sfrs9 (e-PCR), detects polymorphism
- UniSTS:479270

D18382 (e-PCR)
- UniSTS:124776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to alkaloid	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 9

Names: splicing factor, arginine/serine-rich 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025573.3 → NP_079849.1 serine/arginine-rich splicing factor 9

See identical proteins and their annotated locations for NP_079849.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AC117735

Consensus CDS

CCDS19587.1

UniProtKB/Swiss-Prot

Q9CRN3, Q9D0B0

UniProtKB/TrEMBL

Q3TXM9

Related

ENSMUSP00000031513.8, ENSMUST00000031513.14

Conserved Domains (2) summary

cd12598
Location:16 → 87

RRM1_SRSF9; RNA recognition motif 1 in vertebrate serine/arginine-rich splicing factor 9 (SRSF9)

cd12768
Location:112 → 187

RRM2_SRSF9; RNA recognition motif 2 in vertebrate serine/arginine-rich splicing factor 9 (SRSF9)

RNA

NR_036616.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon with an in-frame stop codon. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so this variant is not thought to be protein-coding.

Source sequence(s)

AC117735, AI503042, CJ162734, CV558546