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Fxyd4 FXYD domain-containing ion transport regulator 4 [ Mus musculus (house mouse) ]

Gene ID: 108017, updated on 27-Nov-2024

Summary

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Official Symbol
Fxyd4provided by MGI
Official Full Name
FXYD domain-containing ion transport regulator 4provided by MGI
Primary source
MGI:MGI:1889005
See related
Ensembl:ENSMUSG00000004988 AllianceGenome:MGI:1889005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chif; 0610008I02Rik
Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney adult (RPKM 19.0), ovary adult (RPKM 6.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Fxyd4 in Genome Data Viewer
Location:
6 F1; 6 55.7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117910519..117914668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117933558..117937714, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17123 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850148-117850426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850781-117850973 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1069 Neighboring gene STARR-seq mESC enhancer starr_17127 Neighboring gene heterogeneous nuclear ribonucleoprotein F Neighboring gene STARR-seq mESC enhancer starr_17129 Neighboring gene STARR-seq mESC enhancer starr_17131 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene RasGEF domain family, member 1A Neighboring gene STARR-seq mESC enhancer starr_17132 Neighboring gene STARR-seq mESC enhancer starr_17134 Neighboring gene microRNA 7044

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kidney and colon electrolyte transport in CHIF knockout mice. Goldschmidt I, et al. Cell Physiol Biochem, 2004. PMID 14976412
  2. Generation and phenotypic analysis of CHIF knockout mice. Aizman R, et al. Am J Physiol Renal Physiol, 2002 Sep. PMID 12167609
  3. FXYD3 (Mat-8), a new regulator of Na,K-ATPase. Crambert G, et al. Mol Biol Cell, 2005 May. PMID 15743908, Free PMC Article
  4. FXYD proteins: new regulators of Na-K-ATPase. Geering K. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403837
  5. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, et al. Genomics, 2000 Aug 15. PMID 10950925

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107631

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of sodium:potassium-exchanging ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
FXYD domain-containing ion transport regulator 4
Names
channel inducing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173372.1 → NP_001166843.1  FXYD domain-containing ion transport regulator 4 precursor

    See identical proteins and their annotated locations for NP_001166843.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018728, AU041511
    Consensus CDS
    CCDS20468.1
    UniProtKB/Swiss-Prot
    Q9D2W0
    UniProtKB/TrEMBL
    A0A0N4SVN7
    Related
    ENSMUSP00000145302.2, ENSMUST00000204214.3
    Conserved Domains (1) summary
    pfam02038
    Location:25 → 70
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

  2. NM_033648.1 → NP_387468.1  FXYD domain-containing ion transport regulator 4 precursor

    See identical proteins and their annotated locations for NP_387468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK018728, BC086918
    Consensus CDS
    CCDS20468.1
    UniProtKB/Swiss-Prot
    Q9D2W0
    UniProtKB/TrEMBL
    A0A0N4SVN7
    Related
    ENSMUSP00000005114.8, ENSMUST00000005114.10
    Conserved Domains (1) summary
    pfam02038
    Location:25 → 70
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    117910519..117914668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505295.5 → XP_006505358.1  FXYD domain-containing ion transport regulator 4 isoform X2

    See identical proteins and their annotated locations for XP_006505358.1

    UniProtKB/Swiss-Prot
    Q9D2W0
    UniProtKB/TrEMBL
    A0A0N4SVN7
    Related
    ENSMUSP00000144700.2, ENSMUST00000203082.3
    Conserved Domains (1) summary
    pfam02038
    Location:25 → 70
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

  2. XM_017321297.3 → XP_017176786.1  FXYD domain-containing ion transport regulator 4 isoform X1

    Conserved Domains (1) summary
    pfam02038
    Location:89 → 134
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2W0.1 GenPept UniProtKB/Swiss-Prot:Q9D2W0

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