Slc14a1 solute carrier family 14 (urea transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc14a1provided by MGI
Official Full Name: solute carrier family 14 (urea transporter), member 1provided by MGI
Primary source: MGI:MGI:1351654
See related: Ensembl:ENSMUSG00000059336 AllianceGenome:MGI:1351654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UT-B; Utb1; 2610507K20Rik; 3021401A05Rik
Summary: Enables urea transmembrane transporter activity and water transmembrane transporter activity. Acts upstream of or within establishment of localization in cell; urea transport; and water transport. Located in basolateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; limb; musculature; and sensory organ. Orthologous to human SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 19.4), bladder adult (RPKM 19.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 52.49 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (78143306..78185334, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (78100091..78142119, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells.
Title: Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells.
Water transport mediated by murine urea transporters: implications for urine concentration mechanisms.
Title: Water transport mediated by murine urea transporters: implications for urine concentration mechanisms.
results suggest that the depletion of SLC14alpha1 gene in mice may contribute to the HS-induced abnormality of sodium transportation in the CSF
Title: High salt diet elevates the mean arterial pressure of SLC14α1 gene depletion mice.
functional deficiency of all UTs caused a urea-selective urine-concentrating defect with little physiological abnormality in extrarenal organs.
Title: Generation and phenotypic analysis of mice lacking all urea transporters.
We conclude that transgenic expression of UT-A1 restores basal urea permeability to the level in wild-type mice but does not restore vasopressin-stimulated levels of urea permeability. This information suggests that transgenic expression of UT-A1 alone in mice lacking UT-A1 and UT-A3 is sufficient to restore urine-concentrating ability
Title: Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.
These results demonstrate that the descending thin limb (DTL) of the intermediate loop is composed of type I epithelium and expresses both UT-A2. The functional role of the DTL of the intermediate loop may be distinct from the short or long loops.
Title: Descending thin limb of the intermediate loop expresses both aquaporin 1 and urea transporter A2 in the mouse kidney.
Studies indicate that urea transporter Slc14a1 UT-B is an indispensable transporter involved in maintaining physiological functions in different tissues.
Title: Extrarenal phenotypes of the UT-B knockout mouse.
Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes.
Title: Transport characteristics of urea transporter-B.
Data suggest that urea transporter UT-B may play an important role in protecting bladder urothelium by balancing intracellular urea concentration.
Title: Urea transporter UT-B deletion induces DNA damage and apoptosis in mouse bladder urothelium.
Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity.
Title: A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

Slc14a1 (e-PCR), detects polymorphism
- UniSTS:158759

Slc14a1 (e-PCR), detects polymorphism
- UniSTS:527541

BE102916 (e-PCR)
- UniSTS:244405

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables urea channel activity	ISO Inferred from Sequence Orthology more info
enables urea channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables urea transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables urea transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in urea transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within urea transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urea transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within water transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within water transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: urea transporter 1

Names: solute carrier family 14 member 1; urea transporter B; urea transporter, erythrocyte

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171010.1 → NP_001164481.1 urea transporter 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC112792, BC062816, BC086673, BY231473

Consensus CDS

CCDS50330.1

UniProtKB/Swiss-Prot

Q8VHL0

Related

ENSMUSP00000125114.2, ENSMUST00000160292.8

Conserved Domains (1) summary

pfam03253
Location:111 → 394

UT; Urea transporter
NM_001171011.1 → NP_001164482.1 urea transporter 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AK041979, BC062816, BC086673

Consensus CDS

CCDS29360.1

UniProtKB/Swiss-Prot

Q3U542, Q497G1, Q5RJG2, Q6PDP4, Q8VHL0, Q9CZX3

Related

ENSMUSP00000125367.2, ENSMUST00000160639.2

Conserved Domains (1) summary

pfam03253
Location:55 → 338

UT; Urea transporter
NM_028122.4 → NP_082398.1 urea transporter 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

BC062816, BC086673, BY231473

Consensus CDS

CCDS29360.1

UniProtKB/Swiss-Prot

Q3U542, Q497G1, Q5RJG2, Q6PDP4, Q8VHL0, Q9CZX3

Related

ENSMUSP00000089421.6, ENSMUST00000091813.12

Conserved Domains (1) summary

pfam03253
Location:55 → 338

UT; Urea transporter