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Rnpepl1 arginyl aminopeptidase (aminopeptidase B)-like 1 [ Mus musculus (house mouse) ]

Gene ID: 108657, updated on 27-Nov-2024

Summary

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Official Symbol
Rnpepl1provided by MGI
Official Full Name
arginyl aminopeptidase (aminopeptidase B)-like 1provided by MGI
Primary source
MGI:MGI:1914170
See related
Ensembl:ENSMUSG00000026269 AllianceGenome:MGI:1914170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110014H17Rik
Summary
Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Is expressed in central nervous system and retina. Orthologous to human RNPEPL1 (arginyl aminopeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 84.6), duodenum adult (RPKM 84.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Rnpepl1 in Genome Data Viewer
Location:
1 D; 1 46.6 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92837697..92848307)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92910377..92920585)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene predicted gene, 57577 Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene dual specificity phosphatase 28 Neighboring gene STARR-seq mESC enhancer starr_01722 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:94830898-94831081 Neighboring gene STARR-positive B cell enhancer ABC_E4335 Neighboring gene calpain 10 Neighboring gene G protein-coupled receptor 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloaminopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aminopeptidase RNPEPL1
Names
arginyl aminopeptidase-like 1
methionyl aminopeptidase
NP_852070.3
XP_011246195.1
XP_011246196.1
XP_011246197.1
XP_030111019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181405.4 → NP_852070.3  aminopeptidase RNPEPL1

    Status: VALIDATED

    Source sequence(s)
    AC119846, AV008848, AW488182, BQ559332, CA315475, CA750931, CX213696, CX218581
    Consensus CDS
    CCDS15180.2
    UniProtKB/Swiss-Prot
    G5E872
    Related
    ENSMUSP00000027487.9, ENSMUST00000027487.15
    Conserved Domains (2) summary
    cd09599
    Location:29 → 507
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:524 → 668
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    92837697..92848307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247893.4 → XP_011246195.1  aminopeptidase RNPEPL1 isoform X1

    Conserved Domains (2) summary
    cd09599
    Location:29 → 469
    M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
    pfam09127
    Location:517 → 630
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

  2. XM_011247895.4 → XP_011246197.1  aminopeptidase RNPEPL1 isoform X3

    See identical proteins and their annotated locations for XP_011246197.1

    UniProtKB/TrEMBL
    Q8K2C3
    Conserved Domains (2) summary
    pfam09127
    Location:329 → 442
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:1 → 281
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  3. XM_030255159.2 → XP_030111019.1  aminopeptidase RNPEPL1 isoform X4

    UniProtKB/TrEMBL
    Q8K2C3
    Conserved Domains (2) summary
    pfam09127
    Location:291 → 404
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:1 → 243
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  4. XM_011247894.3 → XP_011246196.1  aminopeptidase RNPEPL1 isoform X2

    UniProtKB/TrEMBL
    Q8K2C3
    Conserved Domains (2) summary
    cd09599
    Location:18 → 358
    M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
    pfam09127
    Location:406 → 519
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E872.2 GenPept UniProtKB/Swiss-Prot:G5E872

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