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ncoa1.S nuclear receptor coactivator 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 108718303, updated on 4-Jan-2025

Summary

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Official Symbol
ncoa1.S
Official Full Name
nuclear receptor coactivator 1 S homeolog
Primary source
Xenbase:XB-GENE-17331286
Locus tag
XELAEV_18030223mg
See related
EnsemblRapid:ENSXLAG00005005307 AllianceGenome:Xenbase:XB-GENE-17331286
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
src1; Xsrc1; src-1; kat13a; rip160; bhlhe42; bhlhe74
Summary
Predicted to enable nuclear receptor binding activity; nuclear receptor coactivator activity; and protein dimerization activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ncoa1.S in Genome Data Viewer
Location:
chromosome: 5S
Exon count:
22
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (139133525..139258537)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (132458752..132587925)

Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108718301 Neighboring gene uncharacterized LOC108718302 Neighboring gene adenylate cyclase type 3-like Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    139133525..139258537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041565116.1 → XP_041421050.1  nuclear receptor coactivator 1 isoform X6

    UniProtKB/TrEMBL
    A0A1L8G5Q8, A0A974HIS9
    Related
    ENSXLAP00005015648.1, ENSXLAT00005015934.1
    Conserved Domains (8) summary
    smart00091
    Location:114 → 171
    PAS; PAS domain
    pfam07469
    Location:1259 → 1315
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:973 → 1016
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:644 → 716
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:259 → 369
    PAS_11; PAS domain
    pfam16279
    Location:734 → 820
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:469 → 626
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl00081
    Location:25 → 73
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. XM_041565118.1 → XP_041421052.1  nuclear receptor coactivator 1 isoform X8

    UniProtKB/TrEMBL
    A0A8J1KUR5
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1050 → 1337
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00081
    Location:51 → 99
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  3. XM_041565115.1 → XP_041421049.1  nuclear receptor coactivator 1 isoform X5

    UniProtKB/TrEMBL
    A0A8J1KXR3
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1161 → 1469
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18948
    Location:51 → 99
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

  4. XM_041565113.1 → XP_041421047.1  nuclear receptor coactivator 1 isoform X3

    UniProtKB/TrEMBL
    A0A8J1KUQ7
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1161 → 1382
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18948
    Location:51 → 99
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

  5. XM_041565114.1 → XP_041421048.1  nuclear receptor coactivator 1 isoform X4

    UniProtKB/TrEMBL
    A0A8J1KWA2
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1161 → 1382
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18948
    Location:51 → 99
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

  6. XM_041565117.1 → XP_041421051.1  nuclear receptor coactivator 1 isoform X7

    UniProtKB/TrEMBL
    A0A8J1KUR4
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1050 → 1338
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00081
    Location:51 → 99
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  7. XM_041565111.1 → XP_041421045.1  nuclear receptor coactivator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J1KUQ2
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1166 → 1500
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18948
    Location:51 → 99
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

  8. XM_041565112.1 → XP_041421046.1  nuclear receptor coactivator 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1KUQ9
    Conserved Domains (3) summary
    smart00091
    Location:140 → 197
    PAS; PAS domain
    pfam09606
    Location:1166 → 1499
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd18948
    Location:51 → 99
    bHLH-PAS_NCoA1_SRC1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 1 (NCoA-1) and similar proteins

  9. XM_018266033.2 → XP_018121522.1  nuclear receptor coactivator 1 isoform X6

    UniProtKB/TrEMBL
    A0A1L8G5Q8, A0A974HIS9
    Related
    ENSXLAP00005015654.1, ENSXLAT00005015940.1
    Conserved Domains (8) summary
    smart00091
    Location:114 → 171
    PAS; PAS domain
    pfam07469
    Location:1259 → 1315
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:973 → 1016
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:644 → 716
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:259 → 369
    PAS_11; PAS domain
    pfam16279
    Location:734 → 820
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:469 → 626
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl00081
    Location:25 → 73
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
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