U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem74b transmembrane protein 74B [ Mus musculus (house mouse) ]

Gene ID: 108832, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tmem74bprovided by MGI
Official Full Name
transmembrane protein 74Bprovided by MGI
Primary source
MGI:MGI:1918629
See related
Ensembl:ENSMUSG00000044364 AllianceGenome:MGI:1918629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430405G05Rik
Summary
Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human TMEM74B (transmembrane protein 74B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 2.6), whole brain E14.5 (RPKM 2.2) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tmem74b in Genome Data Viewer
Location:
2 G3; 2 74.83 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151543294..151558665)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151701805..151716745)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAD21-like (S. pombe) Neighboring gene transmembrane 74B, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06033 Neighboring gene proteasome (prosome, macropain) inhibitor subunit 1 Neighboring gene RIKEN cDNA 4930556L07 gene Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 74B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160363.2 → NP_001153835.1  transmembrane protein 74B

    See identical proteins and their annotated locations for NP_001153835.1

    Status: VALIDATED

    Source sequence(s)
    AL928988
    Consensus CDS
    CCDS50748.1
    UniProtKB/TrEMBL
    A2AU34
    Related
    ENSMUSP00000060017.3, ENSMUST00000060196.3
    Conserved Domains (2) summary
    pfam14927
    Location:99 → 164
    Neurensin; Neurensin
    cl00278
    Location:73 → 123
    CCC1_like; CCC1-related family of proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    151543294..151558665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314899.3 → XP_017170388.1  transmembrane protein 74B isoform X2

    UniProtKB/TrEMBL
    A2AU34

  2. XM_006498562.4 → XP_006498625.1  transmembrane protein 74B isoform X2

    See identical proteins and their annotated locations for XP_006498625.1

    UniProtKB/TrEMBL
    A2AU34
    Related
    ENSMUSP00000105498.2, ENSMUST00000109872.2
    Conserved Domains (2) summary
    pfam14927
    Location:99 → 164
    Neurensin; Neurensin
    cl00278
    Location:73 → 123
    CCC1_like; CCC1-related family of proteins

  3. XM_006498564.5 → XP_006498627.1  transmembrane protein 74B isoform X2

    See identical proteins and their annotated locations for XP_006498627.1

    UniProtKB/TrEMBL
    A2AU34
    Conserved Domains (2) summary
    pfam14927
    Location:99 → 164
    Neurensin; Neurensin
    cl00278
    Location:73 → 123
    CCC1_like; CCC1-related family of proteins

  4. XM_036157424.1 → XP_036013317.1  transmembrane protein 74B isoform X1

    UniProtKB/TrEMBL
    Q8BRL3

  5. XM_006498563.5 → XP_006498626.1  transmembrane protein 74B isoform X2

    See identical proteins and their annotated locations for XP_006498626.1

    UniProtKB/TrEMBL
    A2AU34
    Conserved Domains (2) summary
    pfam14927
    Location:99 → 164
    Neurensin; Neurensin
    cl00278
    Location:73 → 123
    CCC1_like; CCC1-related family of proteins

  6. XM_036157427.1 → XP_036013320.1  transmembrane protein 74B isoform X2

    UniProtKB/TrEMBL
    A2AU34
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools