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CEACAM4 CEA cell adhesion molecule 4 [ Homo sapiens (human) ]

Gene ID: 1089, updated on 27-Nov-2024

Summary

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Official Symbol
CEACAM4provided by HGNC
Official Full Name
CEA cell adhesion molecule 4provided by HGNC
Primary source
HGNC:HGNC:1816
See related
Ensembl:ENSG00000105352 MIM:619159; AllianceGenome:HGNC:1816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCA; CGM7; CGM7_HUMAN
Summary
Predicted to enable protein tyrosine kinase binding activity. Involved in phagocytosis. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bone marrow (RPKM 8.4), spleen (RPKM 4.0) and 4 other tissues See more
Orthologs
all
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Genomic context

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See CEACAM4 in Genome Data Viewer
Location:
19q13.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41613436..41627074, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44435204..44448818, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42125388..42133442, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372404 Neighboring gene CEA cell adhesion molecule pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene uncharacterized LOC105372405

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. Delgado Tascón J, et al. J Leukoc Biol, 2015 Mar. PMID 25567962, Free PMC Article
  2. Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. Kuroki M, et al. J Biol Chem, 1991 Jun 25. PMID 2050678
  3. Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells. Wakabayashi-Nakao K, et al. Biomed Res, 2014. PMID 25152032
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CEACAM4 is expressed in tumor-derived cell lines, and this expression is specific to an medullary thyroid carcinoma derived cell line.
    Title: Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells.
  2. CEACAM4 has phagocytic function.
    Title: The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phagocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 4
Names
Nonspecific cross-reacting antigen (NCA)
carcinoembryonic antigen CGM7
carcinoembryonic antigen gene family member 7
carcinoembryonic antigen related cell adhesion molecule 4
carcinoembryonic antigen-related cell adhesion molecule 4-sv1
carcinoembryonic antigen-related cell adhesion molecule 4-sv2
non-specific cross-reacting antigen W236
nonspecific cross-reacting antigen W236

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362492.2 → NP_001349421.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC243960
    UniProtKB/TrEMBL
    A0A077JJN3
    Conserved Domains (1) summary
    cd05774
    Location:37 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

  2. NM_001362493.2 → NP_001349422.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC243960

  3. NM_001362495.2 → NP_001349424.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC243960
    UniProtKB/TrEMBL
    A0A077JIU5, M0R363
    Related
    ENSP00000473018.1, ENST00000600925.1
    Conserved Domains (1) summary
    cd05774
    Location:37 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

  4. NM_001817.4 → NP_001808.2  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001808.2

    Status: VALIDATED

    Source sequence(s)
    AC005955, AC243960, BF819374, BX644557, BX644579, D90276
    Consensus CDS
    CCDS33033.1
    UniProtKB/Swiss-Prot
    O75871, Q03715, Q7LDZ7
    UniProtKB/TrEMBL
    M0R363
    Related
    ENSP00000221954.2, ENST00000221954.7
    Conserved Domains (2) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:44 → 140
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41613436..41627074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026213.2 → XP_016881702.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

  2. XM_047438093.1 → XP_047294049.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

  3. XM_011526352.2 → XP_011524654.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X12

    See identical proteins and their annotated locations for XP_011524654.1

    UniProtKB/TrEMBL
    M0R363
    Conserved Domains (2) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:44 → 140
    IG_like; Immunoglobulin like

  4. XM_011526354.2 → XP_011524656.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

    See identical proteins and their annotated locations for XP_011524656.1

    UniProtKB/TrEMBL
    M0R363
    Conserved Domains (2) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:44 → 140
    IG_like; Immunoglobulin like

  5. XM_011526343.2 → XP_011524645.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

    See identical proteins and their annotated locations for XP_011524645.1

    UniProtKB/TrEMBL
    M0R363
    Conserved Domains (3) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:44 → 140
    IG_like; Immunoglobulin like
    pfam07332
    Location:146 → 197
    Phage_holin_3_6; Putative Actinobacterial Holin-X, holin superfamily III

  6. XM_047438092.1 → XP_047294048.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

  7. XM_017026200.2 → XP_016881689.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

  8. XM_017026211.2 → XP_016881700.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

    UniProtKB/TrEMBL
    M0R363

  9. XM_017026199.2 → XP_016881688.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

    Conserved Domains (1) summary
    smart00409
    Location:44 → 140
    IG; Immunoglobulin

  10. XM_017026210.2 → XP_016881699.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

    UniProtKB/TrEMBL
    M0R363

  11. XM_011526350.3 → XP_011524652.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

    See identical proteins and their annotated locations for XP_011524652.1

    UniProtKB/TrEMBL
    M0R363
    Conserved Domains (2) summary
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:44 → 140
    IG_like; Immunoglobulin like

  12. XM_017026212.2 → XP_016881701.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

    UniProtKB/TrEMBL
    M0R363

  13. XM_017026206.2 → XP_016881695.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

    UniProtKB/TrEMBL
    M0R363

  14. XM_017026209.2 → XP_016881698.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

    UniProtKB/TrEMBL
    M0R363

  15. XM_047438094.1 → XP_047294050.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

  16. XM_017026207.3 → XP_016881696.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

  17. XM_017026205.2 → XP_016881694.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

    UniProtKB/TrEMBL
    M0R363

RNA

  1. XR_001753593.2 RNA Sequence

  2. XR_007066550.1 RNA Sequence

  3. XR_007066549.1 RNA Sequence

  4. XR_001753592.2 RNA Sequence

  5. XR_007066552.1 RNA Sequence

  6. XR_007066551.1 RNA Sequence

  7. XR_001753594.2 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    54927..68561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329428.1 → XP_054185403.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

  2. XM_054329412.1 → XP_054185387.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

  3. XM_054329395.1 → XP_054185370.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

  4. XM_054329396.1 → XP_054185371.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

  5. XM_054329421.1 → XP_054185396.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

  6. XM_054329398.1 → XP_054185373.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

  7. XM_054329420.1 → XP_054185395.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X12

  8. XM_054329426.1 → XP_054185401.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

  9. XM_054329423.1 → XP_054185398.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X32

  10. XM_054329403.1 → XP_054185378.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X23

  11. XM_054329401.1 → XP_054185376.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X21

  12. XM_054329410.1 → XP_054185385.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X27

  13. XM_054329408.1 → XP_054185383.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X26

  14. XM_054329419.1 → XP_054185394.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X31

  15. XM_054329427.1 → XP_054185402.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X33

  16. XM_054329413.1 → XP_054185388.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X28

  17. XM_054329397.1 → XP_054185372.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X18

  18. XM_054329400.1 → XP_054185375.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X20

  19. XM_054329418.1 → XP_054185393.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X30

  20. XM_054329399.1 → XP_054185374.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X19

  21. XM_054329404.1 → XP_054185379.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X24

  22. XM_054329402.1 → XP_054185377.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X22

  23. XM_054329405.1 → XP_054185380.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X25

  24. XM_054329414.1 → XP_054185389.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X29

  25. XM_054329417.1 → XP_054185392.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

  26. XM_054329407.1 → XP_054185382.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

  27. XM_054329416.1 → XP_054185391.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

  28. XM_054329411.1 → XP_054185386.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

  29. XM_054329415.1 → XP_054185390.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

  30. XM_054329422.1 → XP_054185397.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

  31. XM_054329424.1 → XP_054185399.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X32

  32. XM_054329425.1 → XP_054185400.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X32

  33. XM_054329406.1 → XP_054185381.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

  34. XM_054329409.1 → XP_054185384.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

  35. XM_054329429.1 → XP_054185404.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

RNA

  1. XR_008485639.1 RNA Sequence

  2. XR_008485640.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44435204..44448818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319621.1 → XP_054175596.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

  2. XM_054319610.1 → XP_054175585.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X37

  3. XM_054319605.1 → XP_054175580.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X35

  4. XM_054319620.1 → XP_054175595.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

  5. XM_054319617.1 → XP_054175592.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X12

  6. XM_054319619.1 → XP_054175594.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

  7. XM_054319603.1 → XP_054175578.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

  8. XM_054319618.1 → XP_054175593.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

  9. XM_054319602.1 → XP_054175577.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

  10. XM_054319613.1 → XP_054175588.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

  11. XM_054319601.1 → XP_054175576.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

  12. XM_054319612.1 → XP_054175587.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

  13. XM_054319608.1 → XP_054175583.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X36

  14. XM_054319616.1 → XP_054175591.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X38

  15. XM_054319604.1 → XP_054175579.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X34

  16. XM_054319614.1 → XP_054175589.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

  17. XM_054319615.1 → XP_054175590.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

  18. XM_054319606.1 → XP_054175581.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

  19. XM_054319611.1 → XP_054175586.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

  20. XM_054319622.1 → XP_054175597.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

  21. XM_054319609.1 → XP_054175584.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

  22. XM_054319607.1 → XP_054175582.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

RNA

  1. XR_008485075.1 RNA Sequence

  2. XR_008485073.1 RNA Sequence

  3. XR_008485072.1 RNA Sequence

  4. XR_008485071.1 RNA Sequence

  5. XR_008485074.1 RNA Sequence

  6. XR_008485076.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75871.2 GenPept UniProtKB/Swiss-Prot:O75871

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