Aida axin interactor, dorsalization associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aidaprovided by MGI
Official Full Name: axin interactor, dorsalization associatedprovided by MGI
Primary source: MGI:MGI:1919737
See related: Ensembl:ENSMUSG00000042901 AllianceGenome:MGI:1919737
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610208M17Rik
Summary: Enables protein domain specific binding activity. Involved in negative regulation of JNK cascade and negative regulation of protein-containing complex assembly. Acts upstream of or within negative regulation of JUN kinase activity and regulation of protein-containing complex assembly. Located in cytoplasm. Orthologous to human AIDA (axin interactor, dorsalization associated). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: On Build 36, NM_181732.2 was annotated on chromosome 8 on the reference assembly, chromosome 1 on the Celera assembly, and unplaced on MGSCv3. On Build 37, all placements are on chromosome 1. [04 Sep 2007]
Expression: Ubiquitous expression in CNS E18 (RPKM 15.5), limb E14.5 (RPKM 15.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (183078604..183105356)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (183297060..183324501)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Title: AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
AIDA plays a central role in coordinating the abundance of the enzymes for triacylglycerol synthesis.
Title: AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Aida blocks Axin-mediated JNK activation by disrupting Axin homodimerization. In zebrafish embryos, the dorsalization induced by axin could be repressed by aida. This activity of aida is conferred by its ability to block Axin-mediated JNK activity.
Title: A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of ventral identity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of ventral identity	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dorsal/ventral pattern formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
NOT involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of determination of dorsal identity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: axin interactor, dorsalization-associated protein

Names: axin interaction partner and dorsalization antagonist

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181732.4 → NP_859421.1 axin interactor, dorsalization-associated protein

See identical proteins and their annotated locations for NP_859421.1

Status: VALIDATED

Source sequence(s)

AK081494, BC086763, BY511767

Consensus CDS

CCDS56663.1

UniProtKB/Swiss-Prot

Q3U6V0, Q3UP85, Q6NXY2, Q6PG77, Q78W09, Q8C4Q6, Q99K80

Related

ENSMUSP00000104795.3, ENSMUST00000109166.8

Conserved Domains (2) summary

pfam08910
Location:9 → 112

Aida_N; Aida N-terminus

pfam14186
Location:161 → 299

Aida_C2; Cytoskeletal adhesion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

183078604..183105356

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_145626.3: Suppressed sequence

Description

NM_145626.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.