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Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 [ Mus musculus (house mouse) ]

Gene ID: 109225, updated on 27-Nov-2024

Summary

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Official Symbol
Ms4a7provided by MGI
Official Full Name
membrane-spanning 4-domains, subfamily A, member 7provided by MGI
Primary source
MGI:MGI:1918846
See related
Ensembl:ENSMUSG00000024672 AllianceGenome:MGI:1918846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CFFMA; CD20l4; 9130422I10Rik; A430103C15Rik
Summary
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in body wall mesenchyme and embryo mesenchyme. Orthologous to human MS4A7 (membrane spanning 4-domains A7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 3.2), subcutaneous fat pad adult (RPKM 2.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Ms4a7 in Genome Data Viewer
Location:
19 A; 19 8.43 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11298403..11313510, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11321039..11336146, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526L06 gene Neighboring gene STARR-seq mESC enhancer starr_45568 Neighboring gene membrane-spanning 4-domains, subfamily A, member 5 Neighboring gene STARR-seq mESC enhancer starr_45570 Neighboring gene membrane-spanning 4-domains, subfamily A, member 14 Neighboring gene membrane-spanning 4-domains, subfamily A, member 4A Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic danger signaling triggers TREM2(+) macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. Zhou L, et al. Sci Transl Med, 2024 Mar 13. PMID 38478630
  2. CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity. Srivastava N, et al. Immunity, 2024 Jul 9. PMID 38754432,
  3. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Hammond TR, et al. Immunity, 2019 Jan 15. PMID 30471926, Free PMC Article
  4. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Liang Y, et al. Genomics, 2001 Mar 1. PMID 11401424
  5. A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Rosin JM, et al. Dev Cell, 2021 May 3. PMID 33887203

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic danger signaling triggers TREM2[+] macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
    Title: Hepatic danger signaling triggers TREM2(+) macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane-spanning 4-domains subfamily A member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025610.4 → NP_001020781.1  membrane-spanning 4-domains subfamily A member 7 isoform b

    See identical proteins and their annotated locations for NP_001020781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, differs in the 5' UTR, and uses a downstream start codon compared to variant 3. This variant also lacks an alternate in-frame exon in the 5' coding region compared to variant 3. It encodes isoform b, which is shorter and has a distinct N-terminus compared to isoform c.
    Source sequence(s)
    AC134839, AK018686, AK046559, AK079888
    Consensus CDS
    CCDS29597.1
    UniProtKB/TrEMBL
    Q3U8S2, Q3UAR5, Q9D2W6
    Related
    ENSMUSP00000054830.3, ENSMUST00000056035.9
    Conserved Domains (1) summary
    pfam04103
    Location:47 → 185
    CD20; CD20-like family

  2. NM_001276398.1 → NP_001263327.1  membrane-spanning 4-domains subfamily A member 7 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC134839, AK079888, AK149890
    Consensus CDS
    CCDS70935.1
    UniProtKB/TrEMBL
    E9Q9V5, Q8BV59
    Related
    ENSMUSP00000025574.5, ENSMUST00000025574.11
    Conserved Domains (1) summary
    pfam04103
    Location:80 → 237
    CD20; CD20-like family

  3. NM_027836.6 → NP_082112.3  membrane-spanning 4-domains subfamily A member 7 isoform a

    See identical proteins and their annotated locations for NP_082112.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5' exon structure, differs in the 5' UTR and uses a downstream start codon compared to variant 3. It encodes isoform a which is shorter than isoform c.
    Source sequence(s)
    AC134839, AK046559, AK079888, AK151261
    Consensus CDS
    CCDS29598.1
    UniProtKB/TrEMBL
    Q3U8S2, Q3UAR5, Q99N04
    Related
    ENSMUSP00000064534.5, ENSMUST00000067532.11
    Conserved Domains (1) summary
    pfam04103
    Location:47 → 204
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    11298403..11313510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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