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LOC109286557 enhancer eB upstream of Tbx3 [ Mus musculus (house mouse) ]

Gene ID: 109286557, updated on 9-Aug-2024

Summary

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Gene symbol
LOC109286557
Gene description
enhancer eB upstream of Tbx3
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This region represents an enhancer element, eB, that drives expression of a reporter transgene in the developing heart. This enhancer can synergize with another enhancer, eA, to regulate expression of the T-box 3 (Tbx3) gene, which is located approximately 95 kb downstream. Activity of this sequence is stimulated by GATA binding protein 4 (Gata4) and signaling through bone morphogenetic protein (BMP). [provided by RefSeq, Mar 2019]
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Genomic context

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See LOC109286557 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (119712540..119713656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (119574475..119575591)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42016 Neighboring gene predicted gene, 31314 Neighboring gene STARR-seq mESC enhancer starr_14219 Neighboring gene STARR-seq mESC enhancer starr_14220 Neighboring gene T-box 3, opposite strand 1 Neighboring gene VISTA enhancer mm1177 Neighboring gene predicted gene 16063 Neighboring gene enhancer eA upstream of Tbx3 Neighboring gene predicted gene 16064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system. van Weerd JH, et al. Circ Res, 2014 Aug 1. PMID 24963028

GeneRIFs: Gene References Into Functions

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052573.1 

    Range
    101..1217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    119712540..119713656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version