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KIF2C kinesin family member 2C [ Homo sapiens (human) ]

Gene ID: 11004, updated on 27-Nov-2024

Summary

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Official Symbol
KIF2Cprovided by HGNC
Official Full Name
kinesin family member 2Cprovided by HGNC
Primary source
HGNC:HGNC:6393
See related
Ensembl:ENSG00000142945 MIM:604538; AllianceGenome:HGNC:6393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCAK; CT139; KNSL6
Summary
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues See more
Orthologs
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Genomic context

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See KIF2C in Genome Data Viewer
Location:
1p34.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44739837..44767767)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44610697..44638762)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45205509..45233439)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 1 Neighboring gene uncharacterized LOC105378690 Neighboring gene Sharpr-MPRA regulatory region 12667 Neighboring gene RNA, U5F small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 816 Neighboring gene Sharpr-MPRA regulatory region 12642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45200330-45200889 Neighboring gene RNA, U5D small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 944 Neighboring gene small nucleolar RNA, C/D box 160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 945 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene small nucleolar RNA, C/D box 46 Neighboring gene ribosomal protein S8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C. Wang W, et al. J Biol Chem, 2015 Jul 24. PMID 26055718, Free PMC Article
  2. Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. Ganguly A, et al. Mol Cancer Ther, 2011 Jun. PMID 21471284, Free PMC Article
  3. The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends. Oguchi Y, et al. Nat Cell Biol, 2011 May 22. PMID 21602793
  4. Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe. Gardner MK, et al. Cell, 2011 Nov 23. PMID 22118464
  5. Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer. Sircar K, et al. PLoS One, 2012. PMID 22363599, Free PMC Article

See all (197) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
    Title: Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
  2. Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
    Title: Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
  3. KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.
    Title: KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway.
  4. Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.
    Title: Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.
  5. Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.
    Title: Comprehensive analysis of the effects of KIF2C on prognosis, biological functions and immune infiltration in PAAD.
  6. KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.
    Title: KIF2C affects sperm cell differentiation in patients with Klinefelter syndrome, as revealed by RNA-Seq and scRNA-Seq data.
  7. Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.
    Title: Large-Scale Transcriptome Data Analysis Identifies KIF2C as a Potential Therapeutic Target Associated With Immune Infiltration in Prostate Cancer.
  8. Activation of the TGF-beta1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells.
    Title: Activation of the TGF-β1/Smad signaling by KIF2C contributes to the malignant phenotype of thyroid carcinoma cells.
  9. Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.
    Title: Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays.
  10. KIF2C: a novel link between Wnt/beta-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
    Title: KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
Vpr vpr HIV-1 Vpr upregulates KIF2C in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables centromeric DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule depolymerization TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule plus-end TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF2C
Names
kinesin-like protein 6
mitotic centromere-associated kinesin
testis tissue sperm-binding protein Li 68n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297655.2 → NP_001284584.1  kinesin-like protein KIF2C isoform 2

    See identical proteins and their annotated locations for NP_001284584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB264115, AK300756, BU615368
    UniProtKB/TrEMBL
    A8K3S3, B7Z6Q6
    Conserved Domains (2) summary
    cd01367
    Location:217 → 545
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:223 → 546
    Kinesin; Kinesin motor domain

  2. NM_001297656.2 → NP_001284585.1  kinesin-like protein KIF2C isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as tsMCAK) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK302267, AY026505, BC014924, BU615368, DC404550
    Consensus CDS
    CCDS72774.1
    UniProtKB/TrEMBL
    A8K3S3
    Related
    ENSP00000361291.1, ENST00000372217.5
    Conserved Domains (2) summary
    cd01367
    Location:204 → 532
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:210 → 533
    Kinesin; Kinesin motor domain

  3. NM_001297657.2 → NP_001284586.1  kinesin-like protein KIF2C isoform 4

    See identical proteins and their annotated locations for NP_001284586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK302267, BC014924, BU615368, DC399082
    UniProtKB/TrEMBL
    A8K3S3, B7Z7M6, E9PDS6
    Conserved Domains (2) summary
    cd01367
    Location:145 → 473
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:151 → 474
    Kinesin; Kinesin motor domain

  4. NM_006845.4 → NP_006836.2  kinesin-like protein KIF2C isoform 1

    See identical proteins and their annotated locations for NP_006836.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AU130795, BC008764, BC014924, BU615368
    Consensus CDS
    CCDS512.1
    UniProtKB/Swiss-Prot
    B3ITR9, Q5JR88, Q6ICU1, Q96C18, Q96HB8, Q99661, Q9BWV8
    UniProtKB/TrEMBL
    A0A140VKF1, A8K3S3
    Related
    ENSP00000361298.4, ENST00000372224.9
    Conserved Domains (1) summary
    cd01367
    Location:258 → 586
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    44739837..44767767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441702.1 → XP_047297658.1  kinesin-like protein KIF2C isoform X1

  2. XM_047441708.1 → XP_047297664.1  kinesin-like protein KIF2C isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    44610697..44638762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333958.1 → XP_054189933.1  kinesin-like protein KIF2C isoform X2

  2. XM_054333957.1 → XP_054189932.1  kinesin-like protein KIF2C isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99661.2 GenPept UniProtKB/Swiss-Prot:Q99661

Gene LinkOut

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