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Pgd phosphogluconate dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 110208, updated on 27-Nov-2024

Summary

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Official Symbol
Pgdprovided by MGI
Official Full Name
phosphogluconate dehydrogenaseprovided by MGI
Primary source
MGI:MGI:97553
See related
Ensembl:ENSMUSG00000028961 AllianceGenome:MGI:97553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610042A05Rik
Summary
Enables phosphogluconate dehydrogenase (decarboxylating) activity. Involved in pentose-phosphate shunt, oxidative branch. Acts upstream of or within pentose biosynthetic process. Is active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; axial musculature; liver; and orbito-sphenoid. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 156.7), mammary gland adult (RPKM 135.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pgd in Genome Data Viewer
Location:
4 E2; 4 78.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149234448..149251162, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149149991..149166705, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4730 Neighboring gene STARR-positive B cell enhancer ABC_E11279 Neighboring gene STARR-positive B cell enhancer ABC_E4731 Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene centromere protein S Neighboring gene STARR-positive B cell enhancer ABC_E3554 Neighboring gene kinesin family member 1B Neighboring gene STARR-positive B cell enhancer ABC_E845 Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene ubiquitination factor E4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The modulation of the oxidative phase of the pentose phosphate pathway in mouse liver. Velasco P, et al. Int J Biochem Cell Biol, 1995 Oct. PMID 7496990
  2. Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function. Daneshmandi S, et al. Cell Rep, 2021 Mar 9. PMID 33691103, Free PMC Article
  3. Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c. Rho HK, et al. Biochem Biophys Res Commun, 2005 Jun 24. PMID 15896329
  4. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence. Sukhatme VP, et al. FEBS Lett, 2012 Jul 30. PMID 22677172
  5. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Gao X, et al. Mol Cell, 2019 Dec 19. PMID 31586547, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function.
    Title: Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function.
  2. 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.
    Title: 6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.
  3. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
    Title: Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.
  4. Taken together, these data suggest that ADD1/SREBP1c is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.
    Title: Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphogluconate dehydrogenase (decarboxylating) activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in D-gluconate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-gluconate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in D-gluconate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pentose biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, oxidative branch IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
6-phosphogluconate dehydrogenase, decarboxylating
NP_001074743.1
NP_001343261.1
XP_006538535.1
XP_030108942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081274.2 → NP_001074743.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 1

    See identical proteins and their annotated locations for NP_001074743.1

    Status: VALIDATED

    Source sequence(s)
    AI834806, AK145602, CX212251, CX215938
    Consensus CDS
    CCDS38974.1
    UniProtKB/Swiss-Prot
    Q3UD80, Q9DCD0
    UniProtKB/TrEMBL
    Q91V28
    Related
    ENSMUSP00000081141.7, ENSMUST00000084124.7
    Conserved Domains (3) summary
    PRK09287
    Location:14 → 470
    PRK09287; 6-phosphogluconate dehydrogenase; Validated
    pfam00393
    Location:180 → 469
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    pfam03446
    Location:3 → 176
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase

  2. NM_001356332.1 → NP_001343261.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI834806, AK145602, AL731655, CX212251
    Conserved Domains (1) summary
    pfam00393
    Location:1 → 285
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149234448..149251162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253082.2 → XP_030108942.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

    Conserved Domains (1) summary
    pfam00393
    Location:1 → 285
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

  2. XM_006538472.4 → XP_006538535.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

    Conserved Domains (1) summary
    pfam00393
    Location:1 → 285
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025801.1: Suppressed sequence

    Description
    NM_025801.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCD0.3 GenPept UniProtKB/Swiss-Prot:Q9DCD0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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