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Hivep1 human immunodeficiency virus type I enhancer binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 110521, updated on 27-Nov-2024

Summary

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Official Symbol
Hivep1provided by MGI
Official Full Name
human immunodeficiency virus type I enhancer binding protein 1provided by MGI
Primary source
MGI:MGI:96100
See related
Ensembl:ENSMUSG00000021366 AllianceGenome:MGI:96100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cryabp1
Summary
Enables DNA binding activity and HMG box domain binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 7.2), colon adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hivep1 in Genome Data Viewer
Location:
13 A4; 13 20.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (42205304..42338504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (42051899..42185030)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32555 Neighboring gene STARR-positive B cell enhancer ABC_E925 Neighboring gene STARR-positive B cell enhancer ABC_E5390 Neighboring gene predicted gene 28707 Neighboring gene STARR-positive B cell enhancer mm9_chr13:42189027-42189327 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:42196875-42197076 Neighboring gene predicted gene, 32778 Neighboring gene STARR-seq mESC enhancer starr_34312 Neighboring gene VISTA enhancer mm235 Neighboring gene STARR-seq mESC enhancer starr_34313 Neighboring gene STARR-seq mESC enhancer starr_34315 Neighboring gene endothelin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine transcription factor alpha A-crystallin binding protein I. Complete sequence, gene structure, expression, and functional inhibition via antisense RNA. Brady JP, et al. J Biol Chem, 1995 Jan 20. PMID 7836383
  2. The alpha A-crystallin gene: conserved features of the 5'-flanking regions in human, mouse, and chicken. Jaworski CJ, et al. J Mol Evol, 1991 Dec. PMID 1779432
  3. Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Nakamura T, et al. Mol Cell Biol, 1990 Jul. PMID 1694016, Free PMC Article
  4. Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter. Chong SS, et al. Am J Physiol, 1995 Jun. PMID 7611445
  5. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. Yang X, et al. J Biol Chem, 2005 May 13. PMID 15778499

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development
    Title: Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables HMG box domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 40
Names
HIV type I enhancer binding protein 1
alpha A-CRYBP1
alpha A-crystallin-binding protein 1
alpha A-crystallin-binding protein I
alphaA-CRYBP1
crystallin, alpha binding protein 1
transcription factor alphaA-CRYBP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007772.2 → NP_031798.2  zinc finger protein 40

    See identical proteins and their annotated locations for NP_031798.2

    Status: VALIDATED

    Source sequence(s)
    AC159258
    Consensus CDS
    CCDS36643.1
    UniProtKB/Swiss-Prot
    Q03172
    UniProtKB/TrEMBL
    F8VPM9
    Related
    ENSMUSP00000056147.6, ENSMUST00000060148.6
    Conserved Domains (5) summary
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2076 → 2096
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2074 → 2096
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:2102 → 2167
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    42205304..42338504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516839.5 → XP_006516902.1  zinc finger protein 40 isoform X1

    See identical proteins and their annotated locations for XP_006516902.1

    UniProtKB/Swiss-Prot
    Q03172
    Conserved Domains (6) summary
    smart00451
    Location:2099 → 2130
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2298 → 2691
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2076 → 2096
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2074 → 2096
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006516840.5 → XP_006516903.1  zinc finger protein 40 isoform X1

    See identical proteins and their annotated locations for XP_006516903.1

    UniProtKB/Swiss-Prot
    Q03172
    Conserved Domains (6) summary
    smart00451
    Location:2099 → 2130
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2298 → 2691
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2076 → 2096
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2074 → 2096
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017315358.3 → XP_017170847.1  zinc finger protein 40 isoform X1

    UniProtKB/Swiss-Prot
    Q03172
    Conserved Domains (6) summary
    smart00451
    Location:2099 → 2130
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2298 → 2691
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2076 → 2096
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2074 → 2096
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030247127.2 → XP_030102987.1  zinc finger protein 40 isoform X2

    UniProtKB/Swiss-Prot
    Q03172
    Conserved Domains (6) summary
    smart00451
    Location:1982 → 2013
    ZnF_U1; U1-like zinc finger
    PHA03247
    Location:2181 → 2574
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:292 → 312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1959 → 1979
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1957 → 1979
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:305 → 329
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03172.1 GenPept UniProtKB/Swiss-Prot:Q03172

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