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LOC110673971 CYP11B2 promoter [ Homo sapiens (human) ]

Gene ID: 110673971, updated on 17-Sep-2024

Summary

Gene symbol
LOC110673971
Gene description
CYP11B2 promoter
Gene type
biological region
Feature type(s)
misc_feature: conserved_region, sequence_alteration
mobile_element
protein_bind
regulatory: TATA_box, enhancer, promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the promoter of the cytochrome P450 family 11 subfamily B member 2 (CYP11B2) gene. Activity of this promoter is induced by angiotensin II and potassium and cyclic AMP through the association of nuclear receptor family members to multiple recognition sites in this sequence. Nuclear receptor subfamily 4 group A members 1 and 2 positively regulate promoter activity, which may be attenuated by nuclear receptor subfamily 5 group A member 1 (Nr5a1/Sf1). An Alu retroelement in the distal region may function as an enhancer of promoter activity. A naturally-occurring sequence polymorphism, rs1799998, affects a binding site for nuclear receptor family members, and was shown to be associated with hypertension. [provided by RefSeq, Jul 2017]
Orthologs
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Genomic context

See LOC110673971 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142917842..142919862)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144061171..144063185)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143999258..144001278)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger HIT-type containing 1 pseudogene 1 Neighboring gene CYP11B1 recombination region Neighboring gene CYP11B1 promoter Neighboring gene cytochrome P450 family 11 subfamily B member 1 Neighboring gene CYP11B2 recombination region Neighboring gene cytochrome P450 family 11 subfamily B member 2 Neighboring gene uncharacterized LOC105375794 Neighboring gene Sharpr-MPRA regulatory region 5092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144033761-144034332 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144063636-144063766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144070153-144070654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144073720-144074227 Neighboring gene LY6E divergent transcript Neighboring gene CDC42 pseudogene 3

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055453.1 

    Range
    101..2121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142917842..142919862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144061171..144063185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)