Mbd6 methyl-CpG binding domain protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mbd6provided by MGI
Official Full Name: methyl-CpG binding domain protein 6provided by MGI
Primary source: MGI:MGI:106378
See related: Ensembl:ENSMUSG00000025409 AllianceGenome:MGI:106378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D10Wsu93e
Summary: Predicted to enable chromatin binding activity. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in chromocenter and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in autism spectrum disorder. Orthologous to human MBD6 (methyl-CpG binding domain protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 36.9), thymus adult (RPKM 30.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127117825..127126738, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127281956..127290869, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

C87049 (e-PCR)
- UniSTS:160051

RH124555 (e-PCR)
- UniSTS:161377

D10Wsu93e (e-PCR), detects polymorphism
- UniSTS:141531

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in chromocenter	IBA Inferred from Biological aspect of Ancestor more info
located_in chromocenter	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methyl-CpG-binding domain protein 6

Names: methyl-CpG-binding protein MBD6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347171.1 → NP_001334100.1 methyl-CpG-binding domain protein 6 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termiini, but is 2 aa shorter than isoform 1.

Source sequence(s)

AC144852, AK158797, BC059015, BC083328, BC096027

Consensus CDS

CCDS83762.1

UniProtKB/Swiss-Prot

E9PWH8, Q3TY92

UniProtKB/TrEMBL

Q4VBD6

Related

ENSMUSP00000112805.2, ENSMUST00000119078.8

Conserved Domains (2) summary

PHA03247
Location:379 → 836

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
NM_001379570.1 → NP_001366499.1 methyl-CpG-binding domain protein 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC144852

UniProtKB/TrEMBL

Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:687 → 1004

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
NM_001379571.1 → NP_001366500.1 methyl-CpG-binding domain protein 6 isoform 4

Status: VALIDATED

Source sequence(s)

AC144852

UniProtKB/TrEMBL

Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:394 → 847

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
NM_033072.3 → NP_149063.2 methyl-CpG-binding domain protein 6 isoform 1

See identical proteins and their annotated locations for NP_149063.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC144852, AK158797, BC059015, BC083328, BC096027

Consensus CDS

CCDS24235.1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Related

ENSMUSP00000026476.7, ENSMUST00000026476.13

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

127117825..127126738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244825.1 → XP_030100685.1 methyl-CpG-binding domain protein 6 isoform X1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
XM_011243266.2 → XP_011241568.1 methyl-CpG-binding domain protein 6 isoform X1

See identical proteins and their annotated locations for XP_011241568.1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
XM_011243267.3 → XP_011241569.1 methyl-CpG-binding domain protein 6 isoform X1

See identical proteins and their annotated locations for XP_011241569.1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
XM_011243270.4 → XP_011241572.1 methyl-CpG-binding domain protein 6 isoform X1

See identical proteins and their annotated locations for XP_011241572.1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
XM_011243268.4 → XP_011241570.1 methyl-CpG-binding domain protein 6 isoform X1

See identical proteins and their annotated locations for XP_011241570.1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
XM_011243269.4 → XP_011241571.1 methyl-CpG-binding domain protein 6 isoform X1

See identical proteins and their annotated locations for XP_011241571.1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
XM_030244826.1 → XP_030100686.1 methyl-CpG-binding domain protein 6 isoform X1

UniProtKB/TrEMBL

E9Q572, Q4VBD6

Conserved Domains (2) summary

PHA03247
Location:379 → 838

PHA03247; large tegument protein UL36; Provisional

cl00110
Location:21 → 86

MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...