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Igl immunoglobulin lambda chain complex [ Mus musculus (house mouse) ]

Gene ID: 111519, updated on 17-Aug-2024

Summary

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Official Symbol
Iglprovided by MGI
Official Full Name
immunoglobulin lambda chain complexprovided by MGI
Primary source
MGI:MGI:96526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igl-x
Summary
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus from the C57BL/6J inbred mouse strain. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. This locus has four J-C clusters and three V segments that constitute two transcriptional units. One of the J-C clusters is incapable of encoding a protein; the J and C gene segments in this cluster are considered pseudogenes. Inbred strains of laboratory mice lack an additional J-C cluster of pseudogenes and several additional V segments that are found in wild mice. [provided by RefSeq, Jul 2008]
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Genomic context

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See Igl in Genome Data Viewer
Location:
16 A3; 16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18845608..19079594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19026858..19260844, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene histone cell cycle regulator Neighboring gene 60S ribosomal protein L27a-like Neighboring gene STARR-positive B cell enhancer ABC_E5530 Neighboring gene STARR-positive B cell enhancer ABC_E392 Neighboring gene STARR-positive B cell enhancer ABC_E11605 Neighboring gene STARR-positive B cell enhancer ABC_E4160 Neighboring gene STARR-seq mESC enhancer starr_40292 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr16:19053115-19053416 Neighboring gene ubiquitin-conjugating enzyme E2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr16:19067426-19067726 Neighboring gene STARR-seq mESC enhancer starr_40294 Neighboring gene STARR-positive B cell enhancer mm9_chr16:19088162-19088462 Neighboring gene uncharacterized LOC105246083 Neighboring gene immunoglobulin lambda joining 3 pseudogene Neighboring gene immunoglobulin lambda constant 1 Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda constant 3 Neighboring gene immunoglobulin lambda joining 3 Neighboring gene immunoglobulin lambda variable 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:19152545-19152846 Neighboring gene STARR-positive B cell enhancer ABC_E1182 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene immunoglobulin lambda constant 4 Neighboring gene immunoglobulin lambda joining 4 Neighboring gene immunoglobulin lambda constant 2 Neighboring gene immunoglobulin lambda joining 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:19246220-19246520 Neighboring gene predicted gene, 35545 Neighboring gene STARR-positive B cell enhancer ABC_E8622 Neighboring gene immunoglobulin lambda variable 3 Neighboring gene immunoglobulin lambda variable 2 Neighboring gene olfactory receptor family 2 subfamily M member 12 Neighboring gene predicted gene, 22158

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B. Hagman J, et al. Genes Dev, 1990 Jun. PMID 2116989
  2. Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. ten Boekel E, et al. Immunity, 1997 Sep. PMID 9324356
  3. Polymorphism of C lambda genes and units of duplication in the genus Mus. Scott CL, et al. J Immunol, 1984 May. PMID 6325541
  4. A new variable region in mouse immunoglobulin lambda light chains. Sanchez P, et al. J Exp Med, 1987 Jul 1. PMID 3110349, Free PMC Article
  5. Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements. Oberdoerffer P, et al. J Exp Med, 2003 May 5. PMID 12719477, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 2 state-4 regions distal to the VlambdaJlambda cassettes are highly conserved . These regions may represent shadow enhancers, which are suspected to serve as booster or redundancy elements for the regulation of many genes.
    Title: Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.
  2. Systematic deletion of known individual hypersensitive sites showed that HS1, which forms the major part of the transcription enhancer, Elambda3-1, is essential for Iglambda recombination and that it also helps to restrict Iglambda stage-specific recombination.
    Title: The Eλ(3-1) enhancer is essential for V(D)J recombination of the murine immunoglobulin lambda light chain locus.
  3. A kappa recombination signal sequence and its flanks support six- to nine-fold higher levels of recombination than a lambda counterpart.
    Title: The recombination difference between mouse kappa and lambda segments is mediated by a pair-wise regulation mechanism.
  4. Immunoglobulin lambda chain deficiency allows heavy (H) chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal.
    Title: Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

General gene information

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Markers

Clone Names

  • MGC6743

General protein information

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Names
immunoglobulin lambda chain complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004051.1 

    Range
    501..234487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18845608..19079594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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