U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WBP4 WW domain binding protein 4 [ Homo sapiens (human) ]

Gene ID: 11193, updated on 11-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
WBP4provided by HGNC
Official Full Name
WW domain binding protein 4provided by HGNC
Primary source
HGNC:HGNC:12739
See related
Ensembl:ENSG00000120688 MIM:604981; AllianceGenome:HGNC:12739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP21; NEDHFDB
Summary
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 9.7), fat (RPKM 9.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See WBP4 in Genome Data Viewer
Location:
13q14.11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (41061509..41084006)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (40280657..40303155)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41635645..41658142)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene E74 like ETS transcription factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41567027-41567568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:41567569-41568109 Neighboring gene regulator of G protein signaling 17 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5288 Neighboring gene tRNA-Glu (anticodon TTC) 1-2 Neighboring gene microRNA 3168 Neighboring gene RNA, 7SL, cytoplasmic 597, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome. Klippel S, et al. J Biol Chem, 2011 Nov 4. PMID 21917930, Free PMC Article
  2. Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. Takahara T, et al. Mol Cell, 2005 Apr 15. PMID 15837427
  3. FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase. Sticht J, et al. Biophys J, 2019 Feb 5. PMID 30558886, Free PMC Article
  4. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. Bedford MT, et al. J Biol Chem, 2000 May 26. PMID 10748127
  5. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). Huang X, et al. J Biol Chem, 2009 Sep 11. PMID 19592703, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase
    Title: FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase.
  2. Biochemical and biophysical analyses revealed that an intrinsically disordered region of FBP21 binds to an extended surface of the C-terminal Sec63 unit of Brr2. Additional contacts in the C-terminal helicase cassette are required for allosteric inhibition of Brr2 helicase activity.
    Title: A new role for FBP21 as regulator of Brr2 helicase activity.
  3. formin-binding protein 21 (FBP21)-tandem-WW domain binding fosters protein recognition in the pre-spliceosome
    Title: Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome.
  4. analysis of the Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21)
    Title: Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21).
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neurodevelopmental disorder with hypotonia, feeding difficulties, facial dysmorphism, and brain abnormalities
MedGen: C5935629 OMIM: 620852 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of WW domain binding protein 4 (formin binding protein 21, WBP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC117310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline-rich region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA cis splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WW domain-binding protein 4
Names
WBP-4
WW domain-containing binding protein 4
domain-containing binding protein 4
formin binding protein 21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007187.5 → NP_009118.1  WW domain-binding protein 4

    See identical proteins and their annotated locations for NP_009118.1

    Status: REVIEWED

    Source sequence(s)
    BC108310, BF513662, CD742574
    Consensus CDS
    CCDS9375.1
    UniProtKB/Swiss-Prot
    B7Z4M2, O75554, Q32P29
    UniProtKB/TrEMBL
    B3KMC8
    Related
    ENSP00000368801.3, ENST00000379487.5
    Conserved Domains (2) summary
    COG5104
    Location:128 → 196
    PRP40; Splicing factor [RNA processing and modification]
    pfam06220
    Location:8 → 44
    zf-U1; U1 zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    41061509..41084006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266245.3 → XP_005266302.1  WW domain-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    B3KMC8
    Conserved Domains (2) summary
    pfam06220
    Location:39 → 75
    zf-U1; U1 zinc finger
    cd00201
    Location:200 → 227
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  2. XM_047430071.1 → XP_047286027.1  WW domain-binding protein 4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    40280657..40303155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374061.1 → XP_054230036.1  WW domain-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    B3KMC8

  2. XM_054374062.1 → XP_054230037.1  WW domain-binding protein 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75554.1 GenPept UniProtKB/Swiss-Prot:O75554

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous