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RNF24 ring finger protein 24 [ Homo sapiens (human) ]

Gene ID: 11237, updated on 27-Nov-2024

Summary

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Official Symbol
RNF24provided by HGNC
Official Full Name
ring finger protein 24provided by HGNC
Primary source
HGNC:HGNC:13779
See related
Ensembl:ENSG00000101236 MIM:612489; AllianceGenome:HGNC:13779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G1L
Summary
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 12.4), brain (RPKM 5.0) and 23 other tissues See more
Orthologs
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Genomic context

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See RNF24 in Genome Data Viewer
Location:
20p13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3927311..4015558, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3958229..4046504, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3907958..3996205, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3869109-3869660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12635 Neighboring gene PANK2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17488 Neighboring gene pantothenate kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3886163-3886663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17489 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60114 Neighboring gene microRNA 103b-2 Neighboring gene microRNA 103a-2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3996195-3997127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3997331-3997932 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:4014121-4014765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17491 Neighboring gene ferritin light chain pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4026722-4027222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:4027223-4027723 Neighboring gene ribosomal protein L21 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Lussier MP, et al. Cell Calcium, 2008 May. PMID 17850865
  2. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134337.3 → NP_001127809.1  RING finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_001127809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, BC039584, BQ181223, CD367454, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    D3DVZ2, D3DVZ3, Q9UMH1, Q9Y225
    Related
    ENSP00000351166.6, ENST00000358395.11
    Conserved Domains (1) summary
    cd16469
    Location:76 → 122
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  2. NM_001134338.3 → NP_001127810.1  RING finger protein 24 isoform 2

    See identical proteins and their annotated locations for NP_001127810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR and includes an alternate segment which uses an upstream AUG codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AL031670, BC000213, BQ181223, CD367454, HY140488
    Consensus CDS
    CCDS46577.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000444711.1, ENST00000545616.2
    Conserved Domains (1) summary
    cd16469
    Location:97 → 143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  3. NM_001321749.2 → NP_001308678.1  RING finger protein 24 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, BQ181223, HY050527, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    D3DVZ2, D3DVZ3, Q9UMH1, Q9Y225
    Conserved Domains (1) summary
    cd16469
    Location:76 → 122
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  4. NM_007219.5 → NP_009150.1  RING finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_009150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript yet it encodes the shorter isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, AL096778, BQ181223, CD367454, HY050527, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    D3DVZ2, D3DVZ3, Q9UMH1, Q9Y225
    Related
    ENSP00000336753.5, ENST00000336095.10
    Conserved Domains (1) summary
    cd16469
    Location:76 → 122
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3927311..4015558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529146.3 → XP_011527448.1  RING finger protein 24 isoform X2

    Conserved Domains (1) summary
    cd16469
    Location:91 → 137
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  2. XM_017027621.2 → XP_016883110.1  RING finger protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd16469
    Location:97 → 143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  3. XM_017027620.2 → XP_016883109.1  RING finger protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd16469
    Location:97 → 143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

  4. XM_047439866.1 → XP_047295822.1  RING finger protein 24 isoform X1

  5. XM_047439865.1 → XP_047295821.1  RING finger protein 24 isoform X1

    Related
    ENSP00000388550.2, ENST00000432261.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3958229..4046504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322915.1 → XP_054178890.1  RING finger protein 24 isoform X2

  2. XM_054322911.1 → XP_054178886.1  RING finger protein 24 isoform X1

  3. XM_054322912.1 → XP_054178887.1  RING finger protein 24 isoform X1

  4. XM_054322914.1 → XP_054178889.1  RING finger protein 24 isoform X1

  5. XM_054322913.1 → XP_054178888.1  RING finger protein 24 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016502.1: Suppressed sequence

    Description
    NM_016502.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y225.1 GenPept UniProtKB/Swiss-Prot:Q9Y225

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