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TMEM106A transmembrane protein 106A [ Homo sapiens (human) ]

Gene ID: 113277, updated on 27-Nov-2024

Summary

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Official Symbol
TMEM106Aprovided by HGNC
Official Full Name
transmembrane protein 106Aprovided by HGNC
Primary source
HGNC:HGNC:28288
See related
Ensembl:ENSG00000184988 AllianceGenome:HGNC:28288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney (RPKM 9.2), appendix (RPKM 4.7) and 23 other tissues See more
Orthologs
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Genomic context

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See TMEM106A in Genome Data Viewer
Location:
17q21.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43211875..43220041)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44070653..44078810)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41363894..41372061)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BRCA1 DNA repair associated Neighboring gene uncharacterized LOC101929767 Neighboring gene uncharacterized LOC124900391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12239 Neighboring gene BRCA1 pseudogene 1 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Sharpr-MPRA regulatory region 10579 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41379300-41379489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41381411-41382085 Neighboring gene coiled-coil domain containing 200 Neighboring gene RNA, U2 small nuclear 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TMEM106A inhibits enveloped virus release from cell surface. Mao D, et al. iScience, 2022 Feb 18. PMID 35198896, Free PMC Article
  2. Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis. Xu D, et al. J Cell Mol Med, 2014 Aug. PMID 24975047, Free PMC Article
  3. Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways. Dai H, et al. Sci Rep, 2015 Jul 28. PMID 26215746, Free PMC Article
  4. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. Garcia-Casado Z, et al. BMC Med Genet, 2011 Oct 11. PMID 21989022, Free PMC Article
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low TMEM106A expression is associated with gastric cancer.
    Title: Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ50420, FLJ50717, FLJ77644, MGC20235, MGC182077, MGC182126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD80 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in CD86 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MHC class II biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of nitric oxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane protein 106A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291586.2 → NP_001278515.1  transmembrane protein 106A isoform a

    See identical proteins and their annotated locations for NP_001278515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AC024051, AK290387, BQ013276
    Consensus CDS
    CCDS11462.1
    UniProtKB/Swiss-Prot
    A8K2X2, B7Z698, Q96A25
    UniProtKB/TrEMBL
    K7ERE2
    Related
    ENSP00000466820.1, ENST00000588659.5
    Conserved Domains (1) summary
    pfam07092
    Location:25 → 252
    DUF1356; Protein of unknown function (DUF1356)

  2. NM_001291587.2 → NP_001278516.1  transmembrane protein 106A isoform b

    See identical proteins and their annotated locations for NP_001278516.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC024051, AK299974, BQ013276
    Consensus CDS
    CCDS74073.1
    UniProtKB/Swiss-Prot
    Q96A25
    Related
    ENSP00000439844.1, ENST00000541594.5
    Conserved Domains (1) summary
    pfam07092
    Location:2 → 204
    DUF1356; Protein of unknown function (DUF1356)

  3. NM_001291588.2 → NP_001278517.1  transmembrane protein 106A isoform c

    See identical proteins and their annotated locations for NP_001278517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AC024051, AK301571, BQ013276
    Consensus CDS
    CCDS77039.1
    UniProtKB/TrEMBL
    B7Z779, K7ERE2
    Related
    ENSP00000439835.1, ENST00000536052.5
    Conserved Domains (1) summary
    pfam07092
    Location:25 → 205
    DUF1356; Protein of unknown function (DUF1356)

  4. NM_145041.4 → NP_659478.1  transmembrane protein 106A isoform a

    See identical proteins and their annotated locations for NP_659478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC024051, AK056132, BQ013276
    Consensus CDS
    CCDS11462.1
    UniProtKB/Swiss-Prot
    A8K2X2, B7Z698, Q96A25
    UniProtKB/TrEMBL
    K7ERE2
    Related
    ENSP00000483246.1, ENST00000612339.4
    Conserved Domains (1) summary
    pfam07092
    Location:25 → 252
    DUF1356; Protein of unknown function (DUF1356)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    43211875..43220041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    44070653..44078810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A25.1 GenPept UniProtKB/Swiss-Prot:Q96A25

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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