U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC113788279 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:38385147-38386346 [ Homo sapiens (human) ]

Gene ID: 113788279, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Gene symbol
LOC113788279
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:38385147-38386346
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. The major subregion was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Two subregions were also shown to be active enhancers by ChIP-STARR-seq in primed human embryonic stem cells, where both are associated with the OCT4 transcription factor and are marked by the H3K27ac and H3K4me1 histone modifications. A subregion was also validated as a functional enhancer by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 4:PromP, inactive/poised promoter, highly conserved) and K562 erythroleukemia cells (group: K562 Activating non-DNase unmatched - State 21:Repr, strong Polycomb repression). This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC113788279 in Genome Data Viewer
Location:
8p
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38527405..38529340)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38804393..38806328)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38384923..38386858)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38257600-38258101 Neighboring gene uncharacterized LOC102723716 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38261681-38262180 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38262831-38263332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38269931-38270603 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38270604-38271277 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38272896-38273666 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38274107-38274772 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38275681-38276444 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38277305-38277806 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38277908-38278453 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38278454-38278998 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38278999-38279544 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38279545-38280088 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38280202-38280702 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38280703-38281203 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38282951-38283642 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38285189-38286186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38287183-38288180 Neighboring gene fibroblast growth factor receptor 1 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38289284-38289961 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38289962-38290638 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38292133-38292640 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38292641-38293146 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38293147-38293653 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38294553-38295054 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38296366-38297156 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38297948-38298737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38298738-38299528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38299529-38300319 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38300320-38301110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38301111-38301900 Neighboring gene ribosomal protein S20 pseudogene 22 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38303357-38303904 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38303905-38304451 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38308051-38308774 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38308775-38309498 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38310223-38310946 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38312456-38313158 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38314169-38314670 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38315184-38316172 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38322798-38323299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38325893-38326879 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38329497-38330290 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38330291-38331084 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38331715-38332697 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38335294-38335795 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38337885-38338386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38342043-38342691 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38342692-38343339 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38343723-38344224 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38345990-38346491 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38347499-38348000 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38348154-38348655 Neighboring gene Sharpr-MPRA regulatory region 7766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38353597-38354164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38354165-38354733 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38359246-38360101 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38360102-38360956 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38360976-38361766 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38361767-38362556 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38368263-38369061 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:38369732-38370310 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:38370311-38370888 Neighboring gene long intergenic non-protein coding RNA 3042 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38376955-38377456 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38379090-38380048 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38386932-38387753 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:38387754-38388574 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38388575-38389395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38389396-38390215 Neighboring gene uncharacterized LOC124901935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38409783-38410284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38422268-38422787 Neighboring gene uncharacterized LOC105379384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38422788-38423306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:38424551-38425084 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:38425085-38425618

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
  3. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  4. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 27252
  • OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38384923-38385890
  • OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38385891-38386858
  • Sharpr-MPRA regulatory region 13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_062572.3 

    Range
    101..2036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38527405..38529340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    38804393..38806328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases