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Nat8f5 N-acetyltransferase 8 (GCN5-related) family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114020, updated on 4-Jan-2025

Summary

Official Symbol
Nat8f5provided by RGD
Official Full Name
N-acetyltransferase 8 (GCN5-related) family member 5provided by RGD
Primary source
RGD:621610
See related
EnsemblRapid:ENSRNOG00000015768 AllianceGenome:RGD:621610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetyltransferase activity. Predicted to act upstream of or within determination of left/right symmetry and heart development. Predicted to be located in membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 63.8), Brain (RPKM 15.0) and 6 other tissues See more
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Genomic context

See Nat8f5 in Genome Data Viewer
Location:
4q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119817788..119842503, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118260323..118285038, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117506731..117531480, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ALMS1, centrosome and basal body associated protein Neighboring gene uncharacterized LOC120102325 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 3 Neighboring gene elastin microfibril interfacer 1, pseudogene 1 Neighboring gene uncharacterized LOC134486602 Neighboring gene N-acetyltransferase 8 Neighboring gene N-acetyltransferase 8, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acetyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
involved_in gastrulation with mouth forming second NAS
Non-traceable Author Statement
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
probable N-acetyltransferase family 8 member 5; probable N-acetyltransferase CML5
Names
camello-like 5
camello-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080884.1NP_543160.1  probable N-acetyltransferase family 8 member 5

    See identical proteins and their annotated locations for NP_543160.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158648
    UniProtKB/Swiss-Prot
    Q9QXS7
    UniProtKB/TrEMBL
    A0A0G2K3E7, A0A9K3Y749, B0BN17
    Related
    ENSRNOP00000077569.1, ENSRNOT00000103696.2
    Conserved Domains (2) summary
    cd04301
    Location:108175
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    COG0456
    Location:101196
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    119817788..119842503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285383.1XP_063141453.1  probable N-acetyltransferase CML5 isoform X1

    UniProtKB/Swiss-Prot
    Q9QXS7
    UniProtKB/TrEMBL
    A0A0G2K3E7, A0A9K3Y749, B0BN17
    Related
    ENSRNOP00000072610.2, ENSRNOT00000084170.3