Cds2 CDP-diacylglycerol synthase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cds2provided by RGD
Official Full Name: CDP-diacylglycerol synthase 2provided by RGD
Primary source: RGD:621186
See related: EnsemblRapid:ENSRNOG00000021265 AllianceGenome:RGD:621186
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and lipid droplet formation. Located in membrane. Orthologous to human CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 506.1), Heart (RPKM 474.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (139967870..140006459)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (119514963..119553555)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (124896657..124935221)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidate cytidylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidate cytidylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CDP-diacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in CDP-diacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet formation	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidate cytidylyltransferase 2

Names: CDP-DAG synthase 2; CDP-DG synthase 2; CDP-DG synthetase 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDS 2; CTP:phosphatidate cytidylyltransferase 2

NP_446095.2

EC 2.7.7.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053643.2 → NP_446095.2 phosphatidate cytidylyltransferase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q91XU8

UniProtKB/TrEMBL

A6HQG0, G3V8W2

Related

ENSRNOP00000028888.1, ENSRNOT00000028888.5

Conserved Domains (1) summary

cl21502
Location:105 → 424

CTP_transf_1; Cytidylyltransferase family