Prss1 serine protease 1 (trypsin 1) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss1provided by MGI
Official Full Name: serine protease 1 (trypsin 1)provided by MGI
Primary source: MGI:MGI:98839
See related: Ensembl:ENSMUSG00000062751 AllianceGenome:MGI:98839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Try1; Try-1; Trygn16
Summary: Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ductus deferens; epididymis; esophagus; and pancreas. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 6 B1; 6 19.6 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41435864..41440720)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41458930..41463786)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-29 can regulate expression of protease activated receptors and tryptase- and trypsin-induced IL-4 production in mast cells.
Title: Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29.
up-regulation of trypsins is one of the key host pathological findings in influenza A-induced myocarditis.
Title: Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis.
Results suggest that regulation of Prss1 and Spink3 expression is involved in the susceptibility to experimentally induced pancreatitis.
Title: Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression.
The experimental results are consistent with our hypothesis, suggesting that K(+) induced ion-exchanges play a critical role in the initiation of trypsin premature activation in ZGs.
Title: K+-induced ion-exchanges trigger trypsin activation in pancreas acinar zymogen granules.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protease, serine, 1

Names: protease, serine 1 (trypsin 1); trypsin 1; trypsinogen 16

NP_444473.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_006980.1

Range

568136..572992

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_053243.2 → NP_444473.1 protease, serine, 1 precursor

See identical proteins and their annotated locations for NP_444473.1

Status: VALIDATED

Source sequence(s)

AC153854

Consensus CDS

CCDS20049.1

UniProtKB/TrEMBL

B9EJ35, Q9Z1R9

Related

ENSMUSP00000031910.8, ENSMUST00000031910.8

Conserved Domains (2) summary

smart00020
Location:23 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:24 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...