U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 [ Mus musculus (house mouse) ]

Gene ID: 114664, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Hsd17b11provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 11provided by MGI
Primary source
MGI:MGI:2149821
See related
Ensembl:ENSMUSG00000029311 AllianceGenome:MGI:2149821
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDR2; Dhrs8; Pan1b; retSDR2
Summary
Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen catabolic process. Predicted to be located in cytoplasm. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and sensory organ. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 49.0), duodenum adult (RPKM 48.7) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hsd17b11 in Genome Data Viewer
Location:
5 E5; 5 50.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104137631..104169662, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (103989765..104021796, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kelch-like 8 Neighboring gene predicted gene, 24897 Neighboring gene STARR-positive B cell enhancer mm9_chr5:104356466-104356766 Neighboring gene STARR-seq mESC enhancer starr_13815 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:104436899-104437123 Neighboring gene STARR-seq mESC enhancer starr_13817 Neighboring gene STARR-seq mESC enhancer starr_13818 Neighboring gene STARR-positive B cell enhancer ABC_E2165 Neighboring gene microRNA 5619 Neighboring gene predicted gene, 52783 Neighboring gene nudix hydrolase 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulated expression by PPARalpha and unique localization of 17beta-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver. Yokoi Y, et al. FEBS J, 2007 Sep. PMID 17714510
  2. Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11. Horiguchi Y, et al. Arch Biochem Biophys, 2008 Nov 15. PMID 18804447
  3. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Brereton P, et al. Mol Cell Endocrinol, 2001 Jan 22. PMID 11165019
  4. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. Chai Z, et al. Endocrinology, 2003 May. PMID 12697717
  5. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Sewell W, et al. Dev Biol, 2009 May 15. PMID 19268448, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that 17beta-HSD11 localizes both in the endoplasmic reticulum and in lipid droplets, depending on physiologic conditions
    Title: Regulated expression by PPARalpha and unique localization of 17beta-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in androgen catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
estradiol 17-beta-dehydrogenase 11
Names
17-beta-HSD 11
17-beta-HSD XI
17-beta-hydroxysteroid dehydrogenase 11
17-beta-hydroxysteroid dehydrogenase XI
17bHSD11
17beta-HSD11
17betaHSD11
17betaHSDXI
dehydrogenase/reductase (SDR family) member 8
retinal short-chain dehydrogenase/reductase 2
retinal short-chain dehydrogenase/reductase SDR2
NP_444492.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053262.3 → NP_444492.1  estradiol 17-beta-dehydrogenase 11 precursor

    See identical proteins and their annotated locations for NP_444492.1

    Status: PROVISIONAL

    Source sequence(s)
    AL714024
    Consensus CDS
    CCDS19481.1
    UniProtKB/Swiss-Prot
    Q3U2P6, Q8BR33, Q8C7S0, Q9EQ06
    Related
    ENSMUSP00000031251.10, ENSMUST00000031251.16
    Conserved Domains (2) summary
    cd05339
    Location:38 → 277
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    pfam00106
    Location:37 → 228
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104137631..104169662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQ06.1 GenPept UniProtKB/Swiss-Prot:Q9EQ06

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous