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TMEM132B transmembrane protein 132B [ Homo sapiens (human) ]

Gene ID: 114795, updated on 27-Nov-2024

Summary

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Official Symbol
TMEM132Bprovided by HGNC
Official Full Name
transmembrane protein 132Bprovided by HGNC
Primary source
HGNC:HGNC:29397
See related
Ensembl:ENSG00000139364 MIM:620260; AllianceGenome:HGNC:29397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 6.4), thyroid (RPKM 1.0) and 2 other tissues See more
Orthologs
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Genomic context

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See TMEM132B in Genome Data Viewer
Location:
12q24.31-q24.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (125186386..125662377)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (125194368..125670799)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125670932..126146923)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5080 Neighboring gene NANOG hESC enhancer GRCh37_chr12:125567653-125568164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125575617-125576118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125589377-125589878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125589879-125590378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125605981-125606930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125617807-125618438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125627653-125628227 Neighboring gene uncharacterized LOC105370053 Neighboring gene acetoacetyl-CoA synthetase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125644140-125644640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125670133-125670666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125678461-125678992 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:125691417-125691667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125692947-125693686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125730381-125730881 Neighboring gene uncharacterized LOC105370054 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125764586-125765449 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125765450-125766312 Neighboring gene uncharacterized LOC107984445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125798555-125799056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125813668-125814394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125814395-125815120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5083 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125861407-125861906 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:125893185-125893373 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:125917777-125917975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7322 Neighboring gene NANOG hESC enhancer GRCh37_chr12:125920548-125921070 Neighboring gene Sharpr-MPRA regulatory region 9406 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:126022594-126023793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5084 Neighboring gene uncharacterized LOC105370055 Neighboring gene uncharacterized LOC124903047

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. Farlow JL, et al. PLoS One, 2015. PMID 25803036, Free PMC Article
  2. TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Sanchez-Pulido L, et al. Bioinformatics, 2018 Mar 1. PMID 29088312, Free PMC Article
  3. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. Winham SJ, et al. Mol Psychiatry, 2014 Sep. PMID 24322204
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. Nagase T, et al. DNA Res, 2001 Aug 31. PMID 11572484
  5. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Xie T, et al. Neurobiol Aging, 2014 Jul. PMID 24529757

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM132B is differentially expressed in intracranial aneurysm samples as compared to controls.
    Title: Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37467, KIAA1786, KIAA1906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 132B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286219.2 → NP_001273148.1  transmembrane protein 132B isoform b

    See identical proteins and their annotated locations for NP_001273148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple 5' coding exons, and contains an alternate 5' terminal exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC005146, BC113366, HY012039
    Consensus CDS
    CCDS66501.1
    UniProtKB/Swiss-Prot
    Q14DG7
    Related
    ENSP00000482788.1, ENST00000613307.1
    Conserved Domains (2) summary
    pfam15706
    Location:382 → 465
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:1 → 282
    TMEM132; Transmembrane protein family 132

  2. NM_001366854.1 → NP_001353783.1  transmembrane protein 132B isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004806, AC005146, AC026370, AC093028
    Consensus CDS
    CCDS91772.1
    UniProtKB/TrEMBL
    A0A804HK64
    Related
    ENSP00000507790.1, ENST00000682704.1
    Conserved Domains (3) summary
    pfam15705
    Location:46 → 174
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:875 → 956
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:434 → 775
    TMEM132; Transmembrane protein family 132

  3. NM_052907.3 → NP_443139.2  transmembrane protein 132B isoform a

    See identical proteins and their annotated locations for NP_443139.2

    Status: VALIDATED

    Source sequence(s)
    AB058689, AC005146, AC026370, AC093028, AK093097
    Consensus CDS
    CCDS41859.1
    UniProtKB/Swiss-Prot
    A2RRG8, Q14DG7, Q8NA73, Q96JN9, Q96PY1
    Related
    ENSP00000299308.3, ENST00000299308.7
    Conserved Domains (3) summary
    pfam15705
    Location:41 → 170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:870 → 953
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:429 → 770
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    125186386..125662377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428245.1 → XP_047284201.1  transmembrane protein 132B isoform X4

  2. XM_047428243.1 → XP_047284199.1  transmembrane protein 132B isoform X1

  3. XM_047428241.1 → XP_047284197.1  transmembrane protein 132B isoform X1

  4. XM_047428240.1 → XP_047284196.1  transmembrane protein 132B isoform X1

  5. XM_047428239.1 → XP_047284195.1  transmembrane protein 132B isoform X1

  6. XM_047428242.1 → XP_047284198.1  transmembrane protein 132B isoform X1

  7. XM_017018767.2 → XP_016874256.1  transmembrane protein 132B isoform X1

  8. XM_047428244.1 → XP_047284200.1  transmembrane protein 132B isoform X2

  9. XM_011537854.3 → XP_011536156.1  transmembrane protein 132B isoform X3

    See identical proteins and their annotated locations for XP_011536156.1

    UniProtKB/Swiss-Prot
    Q14DG7
    Conserved Domains (2) summary
    pfam15706
    Location:382 → 465
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:1 → 282
    TMEM132; Transmembrane protein family 132

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    125194368..125670799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371001.1 → XP_054226976.1  transmembrane protein 132B isoform X4

  2. XM_054370998.1 → XP_054226973.1  transmembrane protein 132B isoform X1

  3. XM_054370997.1 → XP_054226972.1  transmembrane protein 132B isoform X1

  4. XM_054370996.1 → XP_054226971.1  transmembrane protein 132B isoform X1

  5. XM_054370995.1 → XP_054226970.1  transmembrane protein 132B isoform X1

  6. XM_054370999.1 → XP_054226974.1  transmembrane protein 132B isoform X1

  7. XM_054371000.1 → XP_054226975.1  transmembrane protein 132B isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14DG7.2 GenPept UniProtKB/Swiss-Prot:Q14DG7

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