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Sorbs2 sorbin and SH3 domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114901, updated on 4-Jan-2025

Summary

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Official Symbol
Sorbs2provided by RGD
Official Full Name
sorbin and SH3 domain containing 2provided by RGD
Primary source
RGD:620061
See related
EnsemblRapid:ENSRNOG00000013391 AllianceGenome:RGD:620061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Argbp2
Summary
Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in cell growth involved in cardiac muscle cell development. Located in dendrite and neuronal cell body. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 391.2), Heart (RPKM 367.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sorbs2 in Genome Data Viewer
Location:
16q11
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53167795..53481300, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46435220..46748743, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (49626205..49820223, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 100 Neighboring gene uncharacterized LOC120097373 Neighboring gene uncharacterized LOC120097374 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120097435 Neighboring gene uncharacterized LOC134482381 Neighboring gene toll-like receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Lee SE, et al. Proc Natl Acad Sci U S A, 2016 Jun 14. PMID 27226294, Free PMC Article
  2. Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy. Nakatani S, et al. Exp Diabetes Res, 2011. PMID 22007191, Free PMC Article
  3. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. Bang C, et al. J Clin Invest, 2014 May. PMID 24743145, Free PMC Article
  4. Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Hallock PT, et al. Mol Cell Biol, 2016 Jan 15. PMID 26527617, Free PMC Article
  5. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. Tosoni D, et al. FEBS Lett, 2009 Jan 22. PMID 19116150

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that nArgBP2 functions to regulate spine morphogenesis and subsequent spine-synapse formation at glutamatergic synapses.
    Title: nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology.
  2. Data suggest that SORBS2 is up-regulated in podocytes of glomeruli and may be associated with development and progression of diabetic nephropathy in a model of type 2 diabetes, possibly through reorganization of actin filaments.
    Title: Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy.
  3. ArgBP2 is a scaffold protein that control the balance between adhesion and motility by coordinating the function of multiple signaling pathways converging on the actin cytoskeleton.
    Title: The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell growth involved in cardiac muscle cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorbin and SH3 domain-containing protein 2
Names
Arg/Abl-interacting protein ArgBP2
arg-binding protein 2
arg/Abl-interacting protein 2
nArgBP2
neural ArgBP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053770.3 → NP_446222.3  sorbin and SH3 domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    O35413, Q923T8
    Related
    ENSRNOP00000098300.2, ENSRNOT00000120667.2
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1136 → 1196
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:962 → 1016
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1037 → 1093
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    53167795..53481300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094137.2 → XP_038950065.1  sorbin and SH3 domain-containing protein 2 isoform X15

    UniProtKB/Swiss-Prot
    O35413, Q923T8
    UniProtKB/TrEMBL
    A6JPR1
    Related
    ENSRNOP00000094779.3, ENSRNOT00000111730.3
    Conserved Domains (4) summary
    smart00459
    Location:167 → 217
    Sorb; Sorbin homologous domain
    cd11917
    Location:1135 → 1195
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:961 → 1015
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1036 → 1092
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

  2. XM_063275002.1 → XP_063131072.1  sorbin and SH3 domain-containing protein 2 isoform X12

    UniProtKB/Swiss-Prot
    O35413, Q923T8
    Related
    ENSRNOP00000089017.2, ENSRNOT00000115009.2

  3. XM_063275036.1 → XP_063131106.1  sorbin and SH3 domain-containing protein 2 isoform X46

    UniProtKB/TrEMBL
    A0A8I5ZQ23
    Related
    ENSRNOP00000098297.2, ENSRNOT00000120664.2

  4. XM_063275034.1 → XP_063131104.1  sorbin and SH3 domain-containing protein 2 isoform X44

    UniProtKB/TrEMBL
    A0A8I5ZV05

  5. XM_063275031.1 → XP_063131101.1  sorbin and SH3 domain-containing protein 2 isoform X41

    UniProtKB/TrEMBL
    A6JPQ9

  6. XM_063275032.1 → XP_063131102.1  sorbin and SH3 domain-containing protein 2 isoform X42

    UniProtKB/TrEMBL
    A6JPR0

  7. XM_063275029.1 → XP_063131099.1  sorbin and SH3 domain-containing protein 2 isoform X40

    UniProtKB/TrEMBL
    A6JPR0

  8. XM_063275028.1 → XP_063131098.1  sorbin and SH3 domain-containing protein 2 isoform X39

    UniProtKB/TrEMBL
    A6JPR0

  9. XM_063275019.1 → XP_063131089.1  sorbin and SH3 domain-containing protein 2 isoform X31

    UniProtKB/TrEMBL
    A0A8I5ZQ23

  10. XM_063275027.1 → XP_063131097.1  sorbin and SH3 domain-containing protein 2 isoform X38

    UniProtKB/TrEMBL
    A6JPR0

  11. XM_063275025.1 → XP_063131095.1  sorbin and SH3 domain-containing protein 2 isoform X37

    UniProtKB/TrEMBL
    A6JPR0

  12. XM_063275024.1 → XP_063131094.1  sorbin and SH3 domain-containing protein 2 isoform X36

    UniProtKB/TrEMBL
    A6JPR0

  13. XM_063275005.1 → XP_063131075.1  sorbin and SH3 domain-containing protein 2 isoform X17

    UniProtKB/Swiss-Prot
    O35413, Q923T8

  14. XM_063275018.1 → XP_063131088.1  sorbin and SH3 domain-containing protein 2 isoform X30

    UniProtKB/TrEMBL
    A6JPR0

  15. XM_063275017.1 → XP_063131087.1  sorbin and SH3 domain-containing protein 2 isoform X29

    UniProtKB/TrEMBL
    A6JPR0

  16. XM_063275010.1 → XP_063131080.1  sorbin and SH3 domain-containing protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A8I6AA99
    Related
    ENSRNOP00000091476.2, ENSRNOT00000113085.2

  17. XM_063275009.1 → XP_063131079.1  sorbin and SH3 domain-containing protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A8I6AA99

  18. XM_063275023.1 → XP_063131093.1  sorbin and SH3 domain-containing protein 2 isoform X35

    UniProtKB/TrEMBL
    A6JPR0

  19. XM_063275022.1 → XP_063131092.1  sorbin and SH3 domain-containing protein 2 isoform X34

    UniProtKB/TrEMBL
    A6JPR0

  20. XM_063275004.1 → XP_063131074.1  sorbin and SH3 domain-containing protein 2 isoform X14

    UniProtKB/Swiss-Prot
    O35413, Q923T8

  21. XM_063275016.1 → XP_063131086.1  sorbin and SH3 domain-containing protein 2 isoform X28

    UniProtKB/TrEMBL
    A0A8I5ZQ23

  22. XM_063275021.1 → XP_063131091.1  sorbin and SH3 domain-containing protein 2 isoform X33

    UniProtKB/TrEMBL
    A6JPR0

  23. XM_063275003.1 → XP_063131073.1  sorbin and SH3 domain-containing protein 2 isoform X13

    UniProtKB/Swiss-Prot
    O35413, Q923T8
    UniProtKB/TrEMBL
    F1LPM3
    Related
    ENSRNOP00000029182.5, ENSRNOT00000029628.8

  24. XM_063275000.1 → XP_063131070.1  sorbin and SH3 domain-containing protein 2 isoform X11

    UniProtKB/Swiss-Prot
    O35413, Q923T8

  25. XM_063275015.1 → XP_063131085.1  sorbin and SH3 domain-containing protein 2 isoform X27

    UniProtKB/TrEMBL
    A6JPR0

  26. XM_063275014.1 → XP_063131084.1  sorbin and SH3 domain-containing protein 2 isoform X26

    UniProtKB/TrEMBL
    A6JPR0

  27. XM_063274998.1 → XP_063131068.1  sorbin and SH3 domain-containing protein 2 isoform X9

    UniProtKB/Swiss-Prot
    O35413, Q923T8
    Related
    ENSRNOP00000098299.1, ENSRNOT00000120666.2

  28. XM_063274997.1 → XP_063131067.1  sorbin and SH3 domain-containing protein 2 isoform X8

    UniProtKB/Swiss-Prot
    O35413, Q923T8

  29. XM_063275013.1 → XP_063131083.1  sorbin and SH3 domain-containing protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A8I6AFA3

  30. XM_063275012.1 → XP_063131082.1  sorbin and SH3 domain-containing protein 2 isoform X24

    UniProtKB/TrEMBL
    A0A8I6AFA3

  31. XM_063274996.1 → XP_063131066.1  sorbin and SH3 domain-containing protein 2 isoform X7

    UniProtKB/Swiss-Prot
    O35413, Q923T8

  32. XM_063275011.1 → XP_063131081.1  sorbin and SH3 domain-containing protein 2 isoform X23

    UniProtKB/TrEMBL
    A0A8I6AA99

  33. XM_063275008.1 → XP_063131078.1  sorbin and SH3 domain-containing protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A8I6AA99

  34. XM_063275007.1 → XP_063131077.1  sorbin and SH3 domain-containing protein 2 isoform X19

    UniProtKB/TrEMBL
    A0A8I6AA99
    Related
    ENSRNOP00000090759.2, ENSRNOT00000096919.2

  35. XM_063275006.1 → XP_063131076.1  sorbin and SH3 domain-containing protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A8I6AA99

  36. XM_063274994.1 → XP_063131064.1  sorbin and SH3 domain-containing protein 2 isoform X5

  37. XM_063274991.1 → XP_063131061.1  sorbin and SH3 domain-containing protein 2 isoform X2

  38. XM_063274995.1 → XP_063131065.1  sorbin and SH3 domain-containing protein 2 isoform X6

  39. XM_063274993.1 → XP_063131063.1  sorbin and SH3 domain-containing protein 2 isoform X4

  40. XM_063274992.1 → XP_063131062.1  sorbin and SH3 domain-containing protein 2 isoform X3

  41. XM_063274989.1 → XP_063131059.1  sorbin and SH3 domain-containing protein 2 isoform X1

  42. XM_063275037.1 → XP_063131107.1  sorbin and SH3 domain-containing protein 2 isoform X46

    UniProtKB/TrEMBL
    A0A8I5ZQ23

  43. XM_063275035.1 → XP_063131105.1  sorbin and SH3 domain-containing protein 2 isoform X45

    UniProtKB/TrEMBL
    A0A8I5ZQ23

  44. XM_063275033.1 → XP_063131103.1  sorbin and SH3 domain-containing protein 2 isoform X43

    UniProtKB/TrEMBL
    A0A8I5ZV05
    Related
    ENSRNOP00000077815.1, ENSRNOT00000118135.3

  45. XM_063275020.1 → XP_063131090.1  sorbin and SH3 domain-containing protein 2 isoform X32

    UniProtKB/TrEMBL
    A0A8I5ZQ23, A0A8I6ABV1

  46. XM_063275030.1 → XP_063131100.1  sorbin and SH3 domain-containing protein 2 isoform X40

    UniProtKB/TrEMBL
    A6JPR0

  47. XM_063275026.1 → XP_063131096.1  sorbin and SH3 domain-containing protein 2 isoform X37

    UniProtKB/TrEMBL
    A6JPR0

  48. XM_039094138.2 → XP_038950066.1  sorbin and SH3 domain-containing protein 2 isoform X16

    UniProtKB/Swiss-Prot
    O35413, Q923T8
    Conserved Domains (4) summary
    cd11917
    Location:1120 → 1180
    SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11920
    Location:946 → 1000
    SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    cd11923
    Location:1021 → 1077
    SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    pfam02208
    Location:170 → 211
    Sorb; Sorbin homologous domain

  49. XM_063274999.1 → XP_063131069.1  sorbin and SH3 domain-containing protein 2 isoform X10

    UniProtKB/Swiss-Prot
    O35413, Q923T8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35413.2 GenPept UniProtKB/Swiss-Prot:O35413

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