Lim2 lens intrinsic membrane protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lim2provided by RGD
Official Full Name: lens intrinsic membrane protein 2provided by RGD
Primary source: RGD:621482
See related: EnsemblRapid:ENSRNOG00000017681 AllianceGenome:RGD:621482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MP17; MP18; MP20; Mp19
Summary: Predicted to be a structural constituent of eye lens. Predicted to act upstream of or within lens development in camera-type eye. Located in vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 19 multiple types. Orthologous to human LIM2 (lens intrinsic membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 7.5), Testes (RPKM 2.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (102974188..102980358)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (93837597..93843769)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (98495082..98501248, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MP20 ia a galectin-3 ligand
Title: MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3.

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:373986 (e-PCR)
- UniSTS:156932

RH127383 (e-PCR)
- UniSTS:210693

RH140867 (e-PCR)
- UniSTS:210693

BG373005 (e-PCR)
- UniSTS:249206

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lens fiber membrane intrinsic protein

Names: lens intrinsic membrane protein 2, 19kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.