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LOC115253421 intestine-critical region regulatory element [ Mus musculus (house mouse) ]

Gene ID: 115253421, updated on 9-Aug-2024

Summary

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Gene symbol
LOC115253421
Gene description
intestine-critical region regulatory element
Gene type
biological region
Feature type(s)
regulatory: promoter
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This genomic element, which is orthologous to the intestine-critical region (ICR) of human chromosome 16, represents the 5' regulatory region of the Percc1 gene on mouse chromosome 17. It can drive expression of a Percc1 reporter transgene in developing mouse gastrointestinal tissues. Deletion of this region in mice results in disrupted intestinal function and loss of Percc1 expression in developing gut, which is consistent with the congenital diarrheal phenotype observed with deletions of the orthologous region in humans. [provided by RefSeq, Jul 2019]
Orthologs
human all
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Genomic context

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See LOC115253421 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25394006..25395517)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25175032..25176543)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 7 Neighboring gene microRNA 12188 Neighboring gene coiled-coil domain containing 154 Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25321285-25321526 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Noncoding deletions reveal a gene that is critical for intestinal function. Oz-Levi D, et al. Nature, 2019 Jul. PMID 31217582, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Other Names

  • Percc1 5' regulatory region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065829.1 

    Range
    101..1612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25394006..25395517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version