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Akap1 A kinase anchor protein 1 [ Mus musculus (house mouse) ]

Gene ID: 11640, updated on 27-Nov-2024

Summary

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Official Symbol
Akap1provided by MGI
Official Full Name
A kinase anchor protein 1provided by MGI
Primary source
MGI:MGI:104729
See related
Ensembl:ENSMUSG00000018428 AllianceGenome:MGI:104729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akap; AKAP84; DAKAP1; AKAP121; S-AKAP84
Summary
Predicted to enable several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in apoptotic process. Located in mitochondrion. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 171.5), heart adult (RPKM 26.9) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Akap1 in Genome Data Viewer
Location:
11 C; 11 54.34 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88721618..88755426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88830792..88864596, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene STARR-seq mESC enhancer starr_30351 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88488860-88488969 Neighboring gene STARR-seq mESC enhancer starr_30353 Neighboring gene STARR-seq mESC enhancer starr_30356 Neighboring gene STARR-seq mESC enhancer starr_30358 Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene STARR-seq mESC enhancer starr_30361 Neighboring gene STARR-positive B cell enhancer ABC_E5262 Neighboring gene STARR-seq mESC enhancer starr_30363 Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene STARR-positive B cell enhancer ABC_E7042 Neighboring gene STARR-seq mESC enhancer starr_30370 Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene predicted gene, 23507 Neighboring gene serine carboxypeptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. Haushalter KJ, et al. Am J Physiol Heart Circ Physiol, 2019 Dec 1. PMID 31674811, Free PMC Article
  2. Assembly of AKAP82, a protein kinase A anchor protein, into the fibrous sheath of mouse sperm. Johnson LR, et al. Dev Biol, 1997 Dec 15. PMID 9441672
  3. Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation. Visconti PE, et al. Dev Biol, 1997 Dec 15. PMID 9441673
  4. A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. Ma Y, et al. J Biol Chem, 2002 Jul 26. PMID 11994283
  5. Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice. Narala VR, et al. Am J Physiol Lung Cell Mol Physiol, 2018 May 1. PMID 29388469, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
    Title: AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
  2. Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
    Title: Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
  3. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
    Title: Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
  4. AKAP121/PKA confers neuroprotection in an in vitro model of oxidative stress induced by exposure to excess glutamate.
    Title: Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress.
  5. genetic disinhibition of Drp1 via knock-out of the mitochondrial protein kinase A (PKA) scaffold AKAP1 exacerbates stroke injury in mice. Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1.
    Title: AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
  6. Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
    Title: Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
  7. Loss of AKAP1 expression is associated with acute lung injury.
    Title: Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice.
  8. these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity.
    Title: A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.
  9. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells.
    Title: Mitochondrial AKAP1 supports mTOR pathway and tumor growth.
  10. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
    Title: Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 1, mitochondrial
Names
A kinase (PRKA) anchor protein 1
D-AKAP-1
PRKA1
S-AKAP
a kinase anchor protein 1, mitochondrial
dual specificity A-kinase-anchoring protein 1
protein kinase A-anchoring protein 1
spermatid A-kinase anchor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042541.1 → NP_001036006.1  A-kinase anchor protein 1, mitochondrial

    See identical proteins and their annotated locations for NP_001036006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK020371, AK132749, AL596180, CJ167452
    Consensus CDS
    CCDS25229.1
    UniProtKB/Swiss-Prot
    B1AR25, O08714, O08715, P97488
    Related
    ENSMUSP00000018572.5, ENSMUST00000018572.11
    Conserved Domains (3) summary
    smart00333
    Location:710 → 768
    TUDOR; Tudor domain
    cd00105
    Location:565 → 625
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:658 → 780
    TUDOR; Tudor domain

  2. NM_009648.2 → NP_033778.2  A-kinase anchor protein 1, mitochondrial

    See identical proteins and their annotated locations for NP_033778.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK020371, AK132749, AL596180
    Consensus CDS
    CCDS25229.1
    UniProtKB/Swiss-Prot
    B1AR25, O08714, O08715, P97488
    Related
    ENSMUSP00000103536.2, ENSMUST00000107903.8
    Conserved Domains (3) summary
    smart00333
    Location:710 → 768
    TUDOR; Tudor domain
    cd00105
    Location:565 → 625
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00567
    Location:658 → 780
    TUDOR; Tudor domain

RNA

  1. NR_104310.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK132749, AK186415, AW985969, BC065135
    Related
    ENSMUST00000143720.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    88721618..88755426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245481.2 → XP_030101341.1  A-kinase anchor protein 1, mitochondrial isoform X1

RNA

  1. XR_388330.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08715.4 GenPept UniProtKB/Swiss-Prot:O08715

Gene LinkOut

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