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Tm4sf4 transmembrane 4 L six family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116467, updated on 27-Nov-2024

Summary

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Symbol
Tm4sf4provided by RGD
Full Name
transmembrane 4 L six family member 4provided by RGD
Primary source
RGD:621784
See related
EnsemblRapid:ENSRNOG00000016437 AllianceGenome:RGD:621784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrtm4
Summary
Involved in tissue regeneration. Predicted to be active in membrane. Orthologous to human TM4SF4 (transmembrane 4 L six family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 907.2) See more
Orthologs
human mouse all
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Genomic context

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See Tm4sf4 in Genome Data Viewer
Location:
2q26
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (143720220..143771283)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (141570321..141621263)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147532032..147547254)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene minichromosome maintenance complex component 4, pseudogene 1 Neighboring gene WW domain containing transcription regulator 1 Neighboring gene ribosomal protein L12, pseudogene 2 Neighboring gene COMM domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4. Qiu J, et al. J Hepatol, 2007 Feb. PMID 17069928
  2. Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1). Liu Z, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267677
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane 4 L6 family member 4
Names
transmembrane 4 superfamily member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053785.2 → NP_446237.1  transmembrane 4 L6 family member 4

    See identical proteins and their annotated locations for NP_446237.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9EQL5
    UniProtKB/TrEMBL
    A6JVG1
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 186
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    143720220..143771283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281154.1 → XP_063137224.1  transmembrane 4 L6 family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQL5
    UniProtKB/TrEMBL
    A6JVG1

  2. XM_039101566.2 → XP_038957494.1  transmembrane 4 L6 family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQL5
    UniProtKB/TrEMBL
    A6JVG1
    Related
    ENSRNOP00000022105.3, ENSRNOT00000022105.6
    Conserved Domains (1) summary
    pfam05805
    Location:1 → 186
    L6_membrane; L6 membrane protein

  3. XM_063281155.1 → XP_063137225.1  transmembrane 4 L6 family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQL5
    UniProtKB/TrEMBL
    A6JVG1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQL5.1 GenPept UniProtKB/Swiss-Prot:Q9EQL5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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