Bak1 BCL2-antagonist/killer 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bak1provided by RGD
Official Full Name: BCL2-antagonist/killer 1provided by RGD
Primary source: RGD:621635
See related: EnsemblRapid:ENSRNOG00000000485 AllianceGenome:RGD:621635
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bak
Summary: Enables several functions, including heat shock protein binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including positive regulation of release of cytochrome c from mitochondria; release of cytochrome c from mitochondria; and response to hydrogen peroxide. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial membrane. Predicted to be part of BAK complex and pore complex. Predicted to be active in mitochondrial outer membrane. Biomarker of intermittent claudication. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 137.4), Spleen (RPKM 106.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (5102334..5111615, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (5100480..5109669, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5609620..5618899, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats.
Title: LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats.
the improvement of cardiac function and structure elicited by miR-125b-5p is in part attributed to repression of the pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes.
Title: A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
qPCR analysis performed at the early phase after ischemia revealed a time dependent decrease in Bax, Bak, and Bcl-x(L) and no alteration in Bcl-2 mRNA expression in response to retinal ischemia.
Title: Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2.
mitochondrial ROS formation, particularly at respiratory chain complex III, is involved in BAK-induced monolayer hyperpermeability
Title: Mitochondrial complex III is involved in proapoptotic BAK-induced microvascular endothelial cell hyperpermeability.
the Hexokinase-mitochondria interaction mediated by Akt has a role in inhibiting apoptosis but does not require Bax and Bak
Title: Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.
Bcl-2, Bid, and Bad inhibit assembly sub-stoichiometrically, whereas peptides from Bak and Bax promote tubulin polymerization at near stoichiometric concentrations
Title: Direct interaction of Bcl-2 proteins with tubulin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20Ztm2 (e-PCR)
- UniSTS:517930

AW534505 (e-PCR)
- UniSTS:246589

BE102269 (e-PCR)
- UniSTS:244111

RH134024 (e-PCR)
- UniSTS:217306

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BH domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables porin activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell negative selection	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of transmembrane electrochemical gradient	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to UV-C	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to fungus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to mycotoxin	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vagina development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BAK complex	ISO Inferred from Sequence Orthology more info
part_of Bcl-2 family protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of pore complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl-2 homologous antagonist/killer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053812.3 → NP_446264.1 bcl-2 homologous antagonist/killer

See identical proteins and their annotated locations for NP_446264.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A6JJK6, F7EQF3, Q5FVT4, Q9JK59

Related

ENSRNOP00000000576.4, ENSRNOT00000000576.7

Conserved Domains (1) summary

cd06845
Location:27 → 181

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

5102334..5111615 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256101.5 → XP_006256163.1 bcl-2 homologous antagonist/killer isoform X1

See identical proteins and their annotated locations for XP_006256163.1

UniProtKB/TrEMBL

A6JJK6, F7EQF3, Q5FVT4, Q9JK59

Conserved Domains (1) summary

cd06845
Location:27 → 181

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
XM_063278930.1 → XP_063135000.1 bcl-2 homologous antagonist/killer isoform X2