Pcsk5 proprotein convertase subtilisin/kexin type 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcsk5provided by RGD
Official Full Name: proprotein convertase subtilisin/kexin type 5provided by RGD
Primary source: RGD:620326
See related: EnsemblRapid:ENSRNOG00000012036 AllianceGenome:RGD:620326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PC6; Pc5
Summary: Predicted to enable peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of integrin-mediated signaling pathway; and positive regulation of smooth muscle cell-matrix adhesion. Located in Golgi apparatus subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 290.0), Lung (RPKM 88.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (224263823..224694350, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (214837847..215267626, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (236031988..236313858)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA3383p regulates ageassociated osteoporosis via targeting PCSK5.
Title: MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5.
downregulation of Pcsk5 during cloaca development into the rectum and urethra might be related to the formation of anorectal malformations.
Title: Spatiotemporal expression of proprotein convertase subtilisin/kexin type 5 in the development of anorectal malformations in fetal rats.
overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
Title: Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
Title: Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
PCSK5A as the gonadotropin-regulated PCSK isoform in the ovary, and its possible contribution to ovulation
Title: Hormonal regulation of proprotein convertase subtilisin/kexin type 5 expression during ovarian follicle development in the rat.
Data suggest that inhibition of furin and PC5 and resulting inhibition of insulin-like growth factor 1 receptor (IGF-1R) activation can inhibit IGF-1-induced membrane-type 1 matrix metalloproteinase activity in vascular smooth muscle cells.
Title: Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.
The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain
Title: Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain.
Activation of alpha(v) integrin by proprotein convertase PC5 is necessary for integrin-mediated adhesion and migration by vascular smooth muscle cells (alpha(v) integrin).
Title: Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

Pcsk5 (e-PCR), detects polymorphism
- UniSTS:507429

BF390451 (e-PCR)
- UniSTS:249472

D19Dcr4 (e-PCR), detects polymorphism
- UniSTS:507557

D1Bda56 (e-PCR)
- UniSTS:239809

RH137520 (e-PCR)
- UniSTS:219608

WI-15571 (e-PCR)
- UniSTS:5604

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cardiac septum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in cytokine precursor processing	IEA Inferred from Electronic Annotation more info
involved_in cytokine precursor processing	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in limb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in peptide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in peptide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
involved_in respiratory tube development	IEA Inferred from Electronic Annotation more info
involved_in respiratory tube development	ISO Inferred from Sequence Orthology more info
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to luteinizing hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in viral life cycle	IEA Inferred from Electronic Annotation more info
involved_in viral life cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proprotein convertase subtilisin/kexin type 5

Names: proprotein convertase 6; subtilisin/kexin-like protease PC5

NP_446275.1

EC 3.4.21.-

XP_038965620.1

EC 3.4.21.-

XP_038965657.1

EC 3.4.21.-

XP_038965700.1

EC 3.4.21.-

XP_038965735.1

EC 3.4.21.-

XP_063120334.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053823.1 → NP_446275.1 proprotein convertase subtilisin/kexin type 5 preproprotein

See identical proteins and their annotated locations for NP_446275.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I0J8

Related

ENSRNOP00000016164.4, ENSRNOT00000016164.9

Conserved Domains (8) summary

cd04059
Location:128 → 422

Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases

smart00261
Location:781 → 825

FU; Furin-like repeats

cd00064
Location:690 → 739

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00082
Location:164 → 447

Peptidase_S8; Subtilase family

pfam01483
Location:507 → 597

P_proprotein; Proprotein convertase P-domain

pfam08686
Location:888 → 912

PLAC; PLAC (protease and lacunin) domain

pfam14843
Location:637 → 751

GF_recep_IV; Growth factor receptor domain IV

pfam16470
Location:40 → 116

S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

224263823..224694350 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109729.2 → XP_038965657.1 proprotein convertase subtilisin/kexin type 5 isoform X2

UniProtKB/TrEMBL

A0A8I6AKB3

Conserved Domains (7) summary

pfam03302
Location:1042 → 1297

VSP; Giardia variant-specific surface protein

cd04059
Location:128 → 422

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:781 → 825

FU; Furin-like repeats

cd00064
Location:1518 → 1566

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam01483
Location:507 → 597

P_proprotein; Proprotein convertase P-domain

pfam14843
Location:637 → 751

GF_recep_IV; Growth factor receptor domain IV

pfam16470
Location:40 → 116

S8_pro-domain; Peptidase S8 pro-domain
XM_039109692.2 → XP_038965620.1 proprotein convertase subtilisin/kexin type 5 isoform X1

UniProtKB/TrEMBL

A0A8I6AKB3

Related

ENSRNOP00000089163.2, ENSRNOT00000100985.2

Conserved Domains (6) summary

pfam03302
Location:1293 → 1618

VSP; Giardia variant-specific surface protein

cd04059
Location:128 → 422

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:1642 → 1684

FU; Furin-like repeats

pfam01483
Location:507 → 597

P_proprotein; Proprotein convertase P-domain

pfam14843
Location:637 → 751

GF_recep_IV; Growth factor receptor domain IV

pfam16470
Location:40 → 116

S8_pro-domain; Peptidase S8 pro-domain
XM_039109772.2 → XP_038965700.1 proprotein convertase subtilisin/kexin type 5 isoform X3

Conserved Domains (5) summary

pfam03302
Location:845 → 1170

VSP; Giardia variant-specific surface protein

smart00261
Location:1043 → 1087

FU; Furin-like repeats

cd00064
Location:1097 → 1145

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam01483
Location:59 → 149

P_proprotein; Proprotein convertase P-domain

pfam14843
Location:189 → 303

GF_recep_IV; Growth factor receptor domain IV
XM_039109807.2 → XP_038965735.1 proprotein convertase subtilisin/kexin type 5 isoform X4

UniProtKB/TrEMBL

A6I0J7

Conserved Domains (4) summary

pfam03302
Location:454 → 779

VSP; Giardia variant-specific surface protein

smart00261
Location:652 → 696

FU; Furin-like repeats

cd00064
Location:706 → 754

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam14843
Location:50 → 156

GF_recep_IV; Growth factor receptor domain IV
XM_063264264.1 → XP_063120334.1 proprotein convertase subtilisin/kexin type 5 isoform X5