Nrxn2 neurexin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nrxn2provided by RGD
Official Full Name: neurexin 2provided by RGD
Primary source: RGD:620211
See related: EnsemblRapid:ENSRNOG00000021103 AllianceGenome:RGD:620211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including calcium channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; postsynapse organization; and regulation of postsynapse assembly. Predicted to be located in cell projection and presynaptic membrane. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 60.7), Spleen (RPKM 8.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213155673..213271526)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203726420..203842301)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221792191..221908047)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurexin-2 is a potential regulator of inflammatory pain in the spinal dorsal horn of rats.
Title: Neurexin-2 is a potential regulator of inflammatory pain in the spinal dorsal horn of rats.
Data show beta-cell expression of the neurexin 2, and demonstrate that the neurexins are expressed outside the central nervous system and help confer an inhibitory synaptic-like phenotype onto the beta-cell surface.
Title: Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion.
beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding.
Title: Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4.
indicate neuronal activity-dependent splicing of NRXN2alpha
Title: Ca2+ -dependent splicing of neurexin IIalpha.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE113844 (e-PCR)
- UniSTS:246817

AU047572 (e-PCR)
- UniSTS:110376

NRXN2_1011 (e-PCR)
- UniSTS:280881

REN55701 (e-PCR)
- UniSTS:380501

REN55957 (e-PCR)
- UniSTS:380757

REN55702 (e-PCR)
- UniSTS:380502

REN55704 (e-PCR)
- UniSTS:380504

REN55975 (e-PCR)
- UniSTS:380775

REN55768 (e-PCR)
- UniSTS:380568

REN55780 (e-PCR)
- UniSTS:380580

AU047975 (e-PCR)
- UniSTS:109996

REN56068 (e-PCR)
- UniSTS:380868

ECD09220 (e-PCR)
- UniSTS:290264

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	ISO Inferred from Sequence Orthology more info
enables neuroligin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in gephyrin clustering involved in postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in gephyrin clustering involved in postsynaptic density assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic density protein 95 clustering	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in social behavior	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in vocal learning	IEA Inferred from Electronic Annotation more info
involved_in vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	IEA Inferred from Electronic Annotation more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurexin-2-beta

Names: neurexin II-alpha; neurexin II-beta; neurexin-2-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053846.2 → NP_446298.2 neurexin-2-beta precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63374, Q63375

Related

ENSRNOP00000101235.1, ENSRNOT00000128084.1

Conserved Domains (6) summary

smart00294
Location:1657 → 1675

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:516 → 666

LamG; Laminin G domain

PHA03247
Location:1433 → 1632

PHA03247; large tegument protein UL36; Provisional

cd00054
Location:694 → 727

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:946 → 1074

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213155673..213271526

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588669.3 → XP_017444158.1 neurexin-2-beta isoform X14

UniProtKB/TrEMBL

A6HZH8
XM_039110513.2 → XP_038966441.1 neurexin-2-beta isoform X15

UniProtKB/TrEMBL

A6HZH8

Conserved Domains (5) summary

smart00294
Location:1463 → 1481

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:516 → 666

LamG; Laminin G domain

cd00054
Location:694 → 727

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:946 → 1074

Laminin_G_2; Laminin G domain
XM_017588661.3 → XP_017444150.1 neurexin-2-beta isoform X1

UniProtKB/Swiss-Prot

Q63374, Q63375
XM_063264586.1 → XP_063120656.1 neurexin-2-beta isoform X19

UniProtKB/TrEMBL

A6HZH8
XM_017588670.3 → XP_017444159.1 neurexin-2-beta isoform X20

UniProtKB/TrEMBL

A6HZH8
XM_017588666.3 → XP_017444155.1 neurexin-2-beta isoform X7

UniProtKB/Swiss-Prot

Q63374, Q63375

Related

ENSRNOP00000108024.1, ENSRNOT00000146175.1
XM_008760062.4 → XP_008758284.1 neurexin-2-beta isoform X16

UniProtKB/TrEMBL

A6HZH8

Conserved Domains (5) summary

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1436 → 1475

Syndecan; Syndecan domain

pfam02210
Location:939 → 1067

Laminin_G_2; Laminin G domain
XM_039110704.2 → XP_038966632.1 neurexin-2-beta isoform X21

UniProtKB/TrEMBL

A0A8I6GML4

Conserved Domains (5) summary

smart00294
Location:1426 → 1444

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:939 → 1067

Laminin_G_2; Laminin G domain
XM_008760063.4 → XP_008758285.1 neurexin-2-beta isoform X18

UniProtKB/TrEMBL

A0A8I5ZY56, A6HZH8

Conserved Domains (5) summary

smart00282
Location:501 → 651

LamG; Laminin G domain

cd00054
Location:679 → 712

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1428 → 1467

Syndecan; Syndecan domain

pfam02210
Location:931 → 1059

Laminin_G_2; Laminin G domain
XM_017588662.3 → XP_017444151.1 neurexin-2-beta isoform X2

UniProtKB/Swiss-Prot

Q63374, Q63375
XM_039110595.2 → XP_038966523.1 neurexin-2-beta isoform X17

UniProtKB/TrEMBL

A6HZH8

Conserved Domains (5) summary

smart00294
Location:1455 → 1473

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:508 → 658

LamG; Laminin G domain

cd00054
Location:686 → 719

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:938 → 1066

Laminin_G_2; Laminin G domain
XM_017588664.3 → XP_017444153.1 neurexin-2-beta isoform X5

UniProtKB/TrEMBL

D3ZAD6
XM_017588665.3 → XP_017444154.1 neurexin-2-beta isoform X6

UniProtKB/TrEMBL

D3ZAD6

Related

ENSRNOP00000085567.1, ENSRNOT00000096608.2
XM_017588668.3 → XP_017444157.1 neurexin-2-beta isoform X12

UniProtKB/TrEMBL

D3ZAD6

Related

ENSRNOP00000101843.1, ENSRNOT00000152771.1
XM_017588667.3 → XP_017444156.1 neurexin-2-beta isoform X11

UniProtKB/TrEMBL

A0A8I6GML4
XM_008760057.4 → XP_008758279.1 neurexin-2-beta isoform X3

UniProtKB/Swiss-Prot

Q63374, Q63375

Conserved Domains (5) summary

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1633 → 1672

Syndecan; Syndecan domain

pfam02210
Location:942 → 1070

Laminin_G_2; Laminin G domain
XM_008760058.4 → XP_008758280.1 neurexin-2-beta isoform X4

UniProtKB/TrEMBL

D3ZAD6

Related

ENSRNOP00000029449.6, ENSRNOT00000031227.9

Conserved Domains (5) summary

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1630 → 1669

Syndecan; Syndecan domain

pfam02210
Location:939 → 1067

Laminin_G_2; Laminin G domain
XM_008760061.4 → XP_008758283.1 neurexin-2-beta isoform X13

UniProtKB/TrEMBL

A0A8I6GML4

Related

ENSRNOP00000097624.2, ENSRNOT00000114181.2

Conserved Domains (5) summary

smart00282
Location:509 → 659

LamG; Laminin G domain

cd00054
Location:687 → 720

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1591 → 1630

Syndecan; Syndecan domain

pfam02210
Location:930 → 1058

Laminin_G_2; Laminin G domain
XM_008760059.4 → XP_008758281.1 neurexin-2-beta isoform X8

UniProtKB/Swiss-Prot

Q63374, Q63375

Conserved Domains (5) summary

smart00282
Location:501 → 651

LamG; Laminin G domain

cd00054
Location:679 → 712

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1625 → 1664

Syndecan; Syndecan domain

pfam02210
Location:934 → 1062

Laminin_G_2; Laminin G domain
XM_008760060.4 → XP_008758282.1 neurexin-2-beta isoform X9

UniProtKB/TrEMBL

D3ZAD6

Related

ENSRNOP00000084528.2, ENSRNOT00000098793.2

Conserved Domains (5) summary

smart00282
Location:501 → 651

LamG; Laminin G domain

cd00054
Location:679 → 712

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:28 → 184

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1622 → 1661

Syndecan; Syndecan domain

pfam02210
Location:931 → 1059

Laminin_G_2; Laminin G domain
XM_063264703.1 → XP_063120773.1 neurexin-2-beta isoform X26

UniProtKB/TrEMBL

A0A8I6GML4
XM_063264423.1 → XP_063120493.1 neurexin-2-beta isoform X10

UniProtKB/TrEMBL

D3ZAD6
XM_039110749.2 → XP_038966677.1 neurexin-2-beta isoform X24

Conserved Domains (3) summary

smart00294
Location:413 → 431

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:393 → 428

Syndecan; Syndecan domain

pfam02210
Location:119 → 267

Laminin_G_2; Laminin G domain
XM_063264626.1 → XP_063120696.1 neurexin-2-beta isoform X22

UniProtKB/Swiss-Prot

Q63376

Related

ENSRNOP00000028651.5, ENSRNOT00000028651.10
XM_063264653.1 → XP_063120723.1 neurexin-2-beta isoform X23
XM_039110788.2 → XP_038966716.1 neurexin-2-beta isoform X25

Conserved Domains (3) summary

smart00294
Location:383 → 401

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:363 → 398

Syndecan; Syndecan domain

pfam02210
Location:119 → 237

Laminin_G_2; Laminin G domain