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Cyth2 cytohesin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116692, updated on 27-Nov-2024

Summary

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Official Symbol
Cyth2provided by RGD
Official Full Name
cytohesin 2provided by RGD
Primary source
RGD:620398
See related
EnsemblRapid:ENSRNOG00000021051 AllianceGenome:RGD:620398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arno; CLM2; Sec7; Pscd2; Sec7B
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and inositol 1,4,5 trisphosphate binding activity. Involved in negative regulation of dendrite development. Located in ruffle. Is extrinsic component of postsynaptic specialization membrane. Orthologous to human CYTH2 (cytohesin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 174.9), Lung (RPKM 159.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyth2 in Genome Data Viewer
Location:
1q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105419631..105427542, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96283182..96291094, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101796349..101803407, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 2B member 1 Neighboring gene uncharacterized LOC134483107 Neighboring gene lemur tyrosine kinase 3 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene glutamate-rich WD repeat containing 1 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Jayaram B, et al. Biochem Pharmacol, 2011 Apr 15. PMID 21276423, Free PMC Article
  2. A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons. Hernández-Deviez D, et al. Traffic, 2007 Dec. PMID 17897316
  3. Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. Cronin TC, et al. EMBO J, 2004 Oct 1. PMID 15359279, Free PMC Article
  4. Regulation of dendritic development by the ARF exchange factor ARNO. Hernández-Deviez DJ, et al. Nat Neurosci, 2002 Jul. PMID 12032543
  5. Localization of mRNAs for subfamily of guanine nucleotide-exchange proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of developing and mature rats under normal and postaxotomy conditions. Suzuki I, et al. Brain Res Mol Brain Res, 2002 Jan 31. PMID 11834294

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
    Title: The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
  2. endotubin labels a distinct endosomal structure in neurons; and ARNO and ARF6 mediate neurite extension through the regulation of this compartment
    Title: A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons.
  3. cytohesin 2 binds to IPCEF1, which modifies its activity
    Title: Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,4,5 trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extrinsic component of postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytohesin-2
Names
ARF nucleotide binding site opener
PH, SEC7 and coiled-coil domain-containing protein 2
SEC7 homolog B
pleckstrin homology, Sec7 and coiled-coil domains 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395066.1 → NP_001381995.1  cytohesin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LSU6
    Related
    ENSRNOP00000028588.6, ENSRNOT00000028588.8
    Conserved Domains (2) summary
    cd01252
    Location:258 → 377
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:61 → 243
    Sec7; Sec7 domain

  2. NM_053911.3 → NP_446363.1  cytohesin-2 isoform 1

    See identical proteins and their annotated locations for NP_446363.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P63035
    UniProtKB/TrEMBL
    F1LSU6
    Conserved Domains (2) summary
    cd01252
    Location:258 → 378
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:61 → 243
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105419631..105427542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63035.1 GenPept UniProtKB/Swiss-Prot:P63035

Gene LinkOut

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