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RragB Ras-related GTP binding B [ Rattus norvegicus (Norway rat) ]

Gene ID: 117043, updated on 4-Jan-2025

Summary

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Official Symbol
RragBprovided by RGD
Official Full Name
Ras-related GTP binding Bprovided by RGD
Primary source
RGD:619805
See related
EnsemblRapid:ENSRNOG00000062421 AllianceGenome:RGD:619805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ragb
Summary
Enables GTP binding activity. Predicted to be involved in several processes, including cellular response to leucine starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGB (Ras related GTP binding B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 134.5), Adrenal (RPKM 27.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See RragB in Genome Data Viewer
Location:
Xq12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (21560313..21610550, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (18184619..18234639, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (19085913..19135049, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ubiquilin 2 Neighboring gene KLF transcription factor 8 Neighboring gene ribosomal protein L35, pseudogene 8 Neighboring gene uncharacterized LOC100909694 Neighboring gene forkhead box R2 Neighboring gene MAGE family member H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. Schürmann A, et al. J Biol Chem, 1995 Dec 1. PMID 7499430
  2. RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. Hirose E, et al. J Cell Sci, 1998 Jan. PMID 9394008
  3. Molecular cloning and characterization of six cDNAs expressed during glucose starvation in excised maize (Zea mays L.) root tips. Chevalier C, et al. Plant Mol Biol, 1995 Jun. PMID 7632917
  4. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Kim YM, et al. Mol Cell, 2012 Jun 29. PMID 22575674, Free PMC Article
  5. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105357

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl ribonucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl ribonucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related GTP-binding protein B
Names
GTP-binding protein ragB
rag B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053972.3 → NP_446424.1  ras-related GTP-binding protein B

    See identical proteins and their annotated locations for NP_446424.1

    Status: VALIDATED

    Source sequence(s)
    BC087698
    UniProtKB/Swiss-Prot
    Q63487, Q6AZ37
    UniProtKB/TrEMBL
    A0A8I5ZR61, A6KL60
    Related
    ENSRNOP00000004235.3, ENSRNOT00000004235.8
    Conserved Domains (1) summary
    cd11384
    Location:42 → 353
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    21560313..21610550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279758.1 → XP_063135828.1  ras-related GTP-binding protein B isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y9L7
    Related
    ENSRNOP00000077577.2, ENSRNOT00000117263.2

  2. XM_063279757.1 → XP_063135827.1  ras-related GTP-binding protein B isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y9L7

  3. XM_039099416.2 → XP_038955344.1  ras-related GTP-binding protein B isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y9L7
    Conserved Domains (1) summary
    cd11384
    Location:42 → 342
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  4. XM_008773109.4 → XP_008771331.2  ras-related GTP-binding protein B isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y9L7, A0A8L2QXU5
    Related
    ENSRNOP00000066990.2, ENSRNOT00000075249.5
    Conserved Domains (1) summary
    cd11384
    Location:42 → 344
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  5. XM_006256775.5 → XP_006256837.1  ras-related GTP-binding protein B isoform X2

    See identical proteins and their annotated locations for XP_006256837.1

    UniProtKB/TrEMBL
    A0A8I5ZR61, A6KL59
    Related
    ENSRNOP00000108946.1, ENSRNOT00000126370.1
    Conserved Domains (1) summary
    cd11384
    Location:42 → 325
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63487.1 GenPept UniProtKB/Swiss-Prot:Q63487

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