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Vip vasoactive intestinal peptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 117064, updated on 27-Nov-2024

Summary

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Official Symbol
Vipprovided by RGD
Official Full Name
vasoactive intestinal peptideprovided by RGD
Primary source
RGD:621647
See related
EnsemblRapid:ENSRNOG00000018808 AllianceGenome:RGD:621647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
vip/phi27
Summary
Enables hormone activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; positive regulation of endothelial cell proliferation; and positive regulation of penile erection. Located in neuronal cell body. Used to study several diseases, including Parkinsonism; brain ischemia; periodontitis; pulmonary hypertension; and uveitis. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in alcohol use disorder and pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 54.8), Adrenal (RPKM 4.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Vip in Genome Data Viewer
Location:
1q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (44470232..44478561)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (42064878..42073219)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (42169307..42177582)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene RNA, U6 small nuclear 959 Neighboring gene myc target 1 Neighboring gene uncharacterized LOC120097707 Neighboring gene F-box protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Therapeutic efficacy of vasoactive intestinal peptide in escherichia coli lipopolysaccharide-induced experimental periodontitis in rats. Gürkan A, et al. J Periodontol, 2009 Oct. PMID 19792856
  2. Vasoactive intestinal peptide can modulate immune and endocrine responses during lipopolysaccharide-induced acute inflammation. Bik W, et al. Neuroimmunomodulation, 2004. PMID 15467350
  3. Vasoactive intestinal peptide protects against ischemic brain damage induced by focal cerebral ischemia in rats. Yang J, et al. Brain Res, 2011 Jun 29. PMID 21620378
  4. Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R(15, 20, 21), L(17), A(24,25), des-N(28)]-VIP-GRR) in experimental asthma/COPD model rats. Onoue S, et al. Int J Pharm, 2011 May 30. PMID 21419198
  5. Vasoactive intestinal polypeptide, an erectile neurotransmitter, improves erectile function more significantly in castrated rats than in normal rats. Zhang MG, et al. BJU Int, 2011 Aug. PMID 21166748

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
    Title: Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury.
  2. Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
    Title: Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression.
  3. Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
    Title: Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.
  4. Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
    Title: Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
  5. VIP could activate neonatal rat primordial follicle through the ERK-mTOR signalling pathway, suggesting a strategy for in vitro primordial follicle recruitment.
    Title: VIP activates primordial follicles of rat through ERK-mTOR pathway in tissue culture.
  6. The expressions of CGRP and VIP were significantly down-regulated in the erectile dysfunction rat model
    Title: [Expressions of calcitonin gene-related peptide and vasoactive intestinal peptide in the penile tissue of the ED rat model and their action mechanisms].
  7. Study shows that sciatic nerve chronic constriction injury that triggers neuropathic pain and persistent disability results in abnormally increased vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide expression in the periaqueductal grey.
    Title: PACAP and VIP expression in the periaqueductal grey of the rat following sciatic nerve constriction injury.
  8. findings indicate that PACAP and VIP can prevent the deleterious effect of Oxygen/Glucose Deprivation on rat neuronal cells.
    Title: The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation.
  9. VIP is an important regulator of cardiovascular and digestive system in physiological and pathological conditions
    Title: Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats.
  10. Data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes.
    Title: Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables type 1 vasoactive intestinal polypeptide receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 1 vasoactive intestinal polypeptide receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables type 2 vasoactive intestinal polypeptide receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in epinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in learning or memory IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of penile erection IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prolactin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
VIP peptides
Names
vasoactive intestinal polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053991.1 → NP_446443.1  VIP peptides preproprotein

    See identical proteins and their annotated locations for NP_446443.1

    Status: VALIDATED

    Source sequence(s)
    BC158798, CB583853
    UniProtKB/Swiss-Prot
    P01283
    UniProtKB/TrEMBL
    A0A090AX27, A0A090BZQ0, A0A1B0GWR8, A6KIN8
    Related
    ENSRNOP00000025477.6, ENSRNOT00000025477.8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 108
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    44470232..44478561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078200.2 → XP_038934128.1  VIP peptides isoform X3

    UniProtKB/TrEMBL
    A0A1B0GWR8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 108
    Hormone_2; Peptide hormone

  2. XM_017588692.3 → XP_017444181.1  VIP peptides isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWR8, B0BNF3
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 107
    Hormone_2; Peptide hormone

  3. XM_017588691.3 → XP_017444180.1  VIP peptides isoform X2

    UniProtKB/TrEMBL
    A0A1B0GWR8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 107
    Hormone_2; Peptide hormone
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01283.2 GenPept UniProtKB/Swiss-Prot:P01283

Gene LinkOut

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