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Cand1 cullin-associated and neddylation-dissociated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117152, updated on 4-Jan-2025

Summary

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Official Symbol
Cand1provided by RGD
Official Full Name
cullin-associated and neddylation-dissociated 1provided by RGD
Primary source
RGD:620479
See related
EnsemblRapid:ENSRNOG00000007834 AllianceGenome:RGD:620479
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tip120; Tip120A
Summary
Enables TBP-class protein binding activity. Involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 356.5), Adrenal (RPKM 333.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cand1 in Genome Data Viewer
Location:
7q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (56566765..56604653, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (54681114..54719002, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (62124362..62162451, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 2 Neighboring gene uncharacterized LOC134479696 Neighboring gene uncharacterized LOC134479697 Neighboring gene ribosomal protein S12, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LncRNA RMRP knockdown promotes proliferation and migration of Schwann cells by mediating the miR-766-5p/CAND1 axis. Zhou L, et al. Neurosci Lett, 2022 Jan 23. PMID 34974108
  2. TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism. Makino Y, et al. Mol Cell Biol, 1999 Dec. PMID 10567521, Free PMC Article
  3. Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1. Fang R, et al. Curr Eye Res, 2024 Apr. PMID 38095165
  4. Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A. Yogosawa S, et al. Biochem Biophys Res Commun, 1999 Dec 9. PMID 10581176
  5. Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Parry G, et al. Semin Cell Dev Biol, 2004 Apr. PMID 15209382

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1.
    Title: Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1.
  2. LncRNA RMRP knockdown promotes proliferation and migration of Schwann cells by mediating the miR-766-5p/CAND1 axis.
    Title: LncRNA RMRP knockdown promotes proliferation and migration of Schwann cells by mediating the miR-766-5p/CAND1 axis.
  3. The findings indicate that CAND1 inhibits the ubiquitylation of rabphilin-3A and positively regulates AVP secretion.
    Title: Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables TBP-class protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in SCF complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cullin-associated NEDD8-dissociated protein 1
Names
TBP-interacting protein 120A
TBP-interacting protein TIP120A
TBP-interacting protein of 120 kDa A
cullin associated and neddylation disassociated 1
cullin-associated and neddylation-dissociated protein 1
p120 CAND1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054004.2 → NP_446456.1  cullin-associated NEDD8-dissociated protein 1

    See identical proteins and their annotated locations for NP_446456.1

    Status: PROVISIONAL

    Source sequence(s)
    D87671
    UniProtKB/Swiss-Prot
    P97536
    UniProtKB/TrEMBL
    A6IGW3
    Related
    ENSRNOP00000010720.3, ENSRNOT00000010720.5
    Conserved Domains (3) summary
    sd00044
    Location:817 → 847
    HEAT; HEAT repeat [structural motif]
    pfam08623
    Location:1040 → 1202
    TIP120; TATA-binding protein interacting (TIP20)
    pfam13513
    Location:150 → 202
    HEAT_EZ; HEAT-like repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    56566765..56604653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97536.1 GenPept UniProtKB/Swiss-Prot:P97536

Gene LinkOut

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